Characterization of molecular mechanisms of DNA repair in mouse olfactory epithelium
| Grant number: | 16/22793-0 |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| Effective date (Start): | February 01, 2017 |
| Effective date (End): | October 31, 2019 |
| Field of knowledge: | Health Sciences - Medicine |
| Principal Investigator: | Paulo Hilário Nascimento Saldiva |
| Grantee: | Nathalia Villa dos Santos |
| Home Institution: | Instituto de Estudos Avançados (IEA). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 13/21728-2 - The use of modern autopsy techniques to investigate human diseases (MODAU), AP.TEM |
Abstract Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by atrophy of the cerebral cortex and loss of cortical and subcortical neurons leading to cognitive impairment and dementia. The olfactory system is one of the first areas affected by AD. Decreased ability to sense detect smells and odors is present in the early diagnosis of AD, even before the cognitive impairment may represent a good accurate and early diagnosis of this disease method. The objectives of this project aims to investigate the association between particulate matter PM2.5, data contained in MODAU database, sociodemographic data collected through interview form and post-mortem analysis of the olfactory system and brain tissue, trying to understand the effects of environmental pollution, quality indexes of life and development of Alzheimer's Disease in residents of São Paulo. (AU) | |