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Alzheimer's Disease in the olfactory epithelium: correlation with the environment

Grant number: 16/22793-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): February 01, 2017
Effective date (End): October 31, 2019
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Paulo Hilário Nascimento Saldiva
Grantee:Nathalia Villa dos Santos
Home Institution: Instituto de Estudos Avançados (IEA). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/21728-2 - The use of modern autopsy techniques to investigate human diseases (MODAU), AP.TEM

Abstract

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by atrophy of the cerebral cortex and loss of cortical and subcortical neurons leading to cognitive impairment and dementia. The olfactory system is one of the first areas affected by AD. Decreased ability to sense detect smells and odors is present in the early diagnosis of AD, even before the cognitive impairment may represent a good accurate and early diagnosis of this disease method. The objectives of this project aims to investigate the association between particulate matter PM2.5, data contained in MODAU database, sociodemographic data collected through interview form and post-mortem analysis of the olfactory system and brain tissue, trying to understand the effects of environmental pollution, quality indexes of life and development of Alzheimer's Disease in residents of São Paulo. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CREMASCO TAKANO, ANA PAULA; JUSTO, LISIE TOCCI; DOS SANTOS, NATHALIA VILLA; MARQUEZINI, MONICA VALERIA; DE ANDRE, PAULO AFONSO; MONTEIRO DA ROCHA, FRANCISCO MARCELO; PASQUALUCCI, CARLOS AUGUSTO; BARROZO, LIGIA VIZEU; SINGER, JULIO M.; SALDIVA DE ANDRE, CARMEN DIVA; NASCIMENTO SALDIVA, PAULO HILARIO; VERAS, MARIANA MATERA. Pleural anthracosis as an indicator of lifetime exposure to urban air pollution: An autopsy-based study in Sao Paulo. Environmental Research, v. 173, p. 23-32, JUN 2019. Web of Science Citations: 0.

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