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Alzheimer's Disease in the olfactory epithelium: correlation with the environment

Grant number: 16/22793-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): February 01, 2017
Effective date (End): October 31, 2019
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal Investigator:Paulo Hilário Nascimento Saldiva
Grantee:Nathalia Villa dos Santos
Host Institution: Instituto de Estudos Avançados (IEA). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/21728-2 - The use of modern autopsy techniques to investigate human diseases (MODAU), AP.TEM


Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by atrophy of the cerebral cortex and loss of cortical and subcortical neurons leading to cognitive impairment and dementia. The olfactory system is one of the first areas affected by AD. Decreased ability to sense detect smells and odors is present in the early diagnosis of AD, even before the cognitive impairment may represent a good accurate and early diagnosis of this disease method. The objectives of this project aims to investigate the association between particulate matter PM2.5, data contained in MODAU database, sociodemographic data collected through interview form and post-mortem analysis of the olfactory system and brain tissue, trying to understand the effects of environmental pollution, quality indexes of life and development of Alzheimer's Disease in residents of São Paulo. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, NATHALIA VILLA; ZILLI VIEIRA, CAROLINA LETICIA; NASCIMENTO SALDIVA, PAULO HILARIO; MAZZILLI, BARBARA PACI; SAIKI, MITIKO; SAUEIA, CATIA HELOISA; SALDIVA DE ANDRE, CARMEN DIVA; JUSTO, LISIE TOCCI; NISTI, MARCELO BESSA; KOUTRAKIS, PETROS. Levels of Polonium-210 in brain and pulmonary tissues: Preliminary study in autopsies conducted in the city of Sao Paulo, Brazil. SCIENTIFIC REPORTS, v. 10, n. 1, . (13/21728-2, 16/03461-7, 16/22793-0, 16/23129-7)
CREMASCO TAKANO, ANA PAULA; JUSTO, LISIE TOCCI; DOS SANTOS, NATHALIA VILLA; MARQUEZINI, MONICA VALERIA; DE ANDRE, PAULO AFONSO; MONTEIRO DA ROCHA, FRANCISCO MARCELO; PASQUALUCCI, CARLOS AUGUSTO; BARROZO, LIGIA VIZEU; SINGER, JULIO M.; SALDIVA DE ANDRE, CARMEN DIVA; et al. Pleural anthracosis as an indicator of lifetime exposure to urban air pollution: An autopsy-based study in Sao Paulo. Environmental Research, v. 173, p. 23-32, . (16/22793-0, 16/23129-7, 16/03461-7, 13/21728-2)
DOS SANTOS, NATHALIA VILLA; YARIWAKE, VICTOR YUJI; MARQUES, KARINA DO VALLE; VERAS, MARIANA MATERA; FAJERSZTAJN, LAIS. Air Pollution: A Neglected Risk Factor for Dementia in Latin America and the Caribbean. FRONTIERS IN NEUROLOGY, v. 12, . (16/22793-0)
DOS SANTOS, NATHALIA VILLA; VIEIRA, CAROLINA LETICIA ZILLI; SALDIVA, PAULO HILARIO NASCIMENTO; DE ANDRE, CARMEN DIVA SALDIVA; MAZZILLI, BARBARA PACI; ANDRADE, MARIA DE FATIMA; SAUEIA, CATIA HELOISA; SAIKI, MITIKO; VERAS, MARIANA MATERA; KOUTRAKIS, PETROS. Accumulation of trace element content in the lungs of Sao Paulo city residents and its correlation to lifetime exposure to air pollution. SCIENTIFIC REPORTS, v. 12, n. 1, p. 7-pg., . (16/22793-0, 13/21728-2, 16/03461-7, 16/23129-7)

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