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The use of modern autopsy techniques to investigate human diseases (MODAU)

Grant number: 13/21728-2
Support type:Research Projects - Thematic Grants
Duration: November 01, 2014 - October 31, 2019
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Paulo Hilário Nascimento Saldiva
Grantee:Paulo Hilário Nascimento Saldiva
Home Institution: Instituto de Estudos Avançados (IEA). Universidade de São Paulo (USP). São Paulo, SP, Brazil
Co-Principal Investigators:Carlos Augusto Gonçalves Pasqualucci ; Edson Amaro Junior ; Elaine Maria Frade Costa ; Gregório Cardoso Tápias Ceccantini ; João Eduardo Ferreira ; Julio da Motta Singer ; Ligia Vizeu Barrozo ; Luiz Fernando Ferraz da Silva ; Marcos Silveira Buckeridge ; Maria de Fátima Andrade ; Marisa Dolhnikoff ; Mitiko Saiki ; Pérola de Castro Vasconcellos ; Thais Mauad
Assoc. researchers:Alexandre Valotta da Silva ; Aline Pivetta Cora ; Ana Luiza de Souza Bierrenbach ; Ana Paula Cremasco Takano ; Antonio Carlos Pedroso de Lima ; Carmen Diva Saldiva de André ; Catia Martinez Minto ; Claudia da Costa Leite ; Claudia Kimie Suemoto ; Gisela Tunes da Silva ; Henrique César Santejo Silveira ; José Marcelo Farfel ; Lea Tenenholz Grinberg ; Leila Antonangelo ; Lucia Maria Machado Bógus ; Lucia Pereira Barroso ; Luiz Alberto Amador Pereira ; Maria de Fátima Andrade ; Maria Lucia Bueno Garcia ; Mariana Matera Veras ; Marina Jorge de Miranda ; Milton de Arruda Martins ; Mônica Valeria Marquezini ; Nelson Ithiro Tanaka ; Paulo Afonso de André ; Paulo Justiniano Ribeiro Junior ; Paulo Sergio Panse Silveira ; Regina Maura de Miranda ; Reinaldo Paul Pérez Machado ; Renata Elaine Paraizo Leite ; Renata Eloah de Lucena Ferretti-Rebustini ; Ricardo Nitrini ; Ruy de Camargo Pires Neto ; Silvia Helena Gelás Lage ; Silvia Regina Dias Medici Saldiva ; Suzana Pasternak ; Tiana Carla Lopes Moreira ; Wilson Jacob Filho
Associated grant(s):16/50192-1 - Evaluation of new alternatives to increase the accuracy of the determination of cause of death: a public health approach, AP.R
15/50081-2 - Achieving sustainable food production and irrigation in São Paulo and Melbourne, AP.R
Associated scholarship(s):18/24085-9 - Expression of RAGE in pulmonary tissue of patients diagnosed with sepsis and acute respiratory distress syndrome, BP.IC
17/06670-9 - Co-benefits of the reduction of atmospheric pollution from the transport of passengers in São Paulo: an integrated economic evaluation of health impacts using different vehicle emission scenarios., BP.PD
17/10515-9 - Biomonitoring using tree bark and its correlation with particulate matter, BP.IC
+ associated scholarships 17/10514-2 - Green areas as filters of atmospheric pollution of vehicular emissions in the city of São Paulo, BP.IC
17/10544-9 - Dendrochronology of Cedrela fissilis from an urban park in São Paulo, BP.IC
17/09486-4 - Digital atlas of pathology, BP.IC
16/23129-7 - Impact of long-term exposure to air pollution on myocardium ageing, BP.PD
16/09411-1 - Spatio-temporal model for predicting the concentration of fine particulate matter (PM 2.5) in Metropolitan Area of São Paulo, BP.DR
16/23339-1 - Molecular characterization and occurrence of organic compounds in gaseous and particulate phase in atmospheric particulate matter collected in Petrochemical Industry of Capuava (SP), BP.DD
16/22793-0 - Alzheimer's Disease in the olfactory epithelium: correlation with the environment, BP.PD
16/15989-6 - Green spaces and health: the impact of green spaces on the population of the Metropolitan Area of São Paulo, BP.PD
16/17936-7 - Secondary aerosol: precursors and contribution to the atmospheric particulate matter, BP.PD
15/25511-3 - Climate and pollution reconstruction based on urban tree-rings growth records, BP.PD
15/03932-7 - MetroHealth data warehouse: multidimensional data visualization and data extract, BP.TT
15/02770-3 - The use of semi-automated and automated strategies for co registration and correlation between radiographic and pathologic image analysis in the central nervous system - a feasibility study, BE.PQ
15/01798-1 - MetroHealth data warehouse: conceptual modeling and implementation, BP.TT - associated scholarships

Abstract

Since ancient times, passing through the first known anatomic studies in the Middle Ages to the use of modern molecular techniques for the study of physiopathological processes, autopsy has shown to be a very rich source of material and inspiration for the advancement of scientific knowledge. Although a wide range of imaging techniques have emerged, several studies have shown that the autopsy remains crucial for: the complete assessment of the disease process, the assessment of new pathologies and quality control of the medical service. Autopsy also allows for the development of concomitant and associated projects in different areas due to the abundance of material. The School of Medicine of the University of Sao Paulo (FMUSP) seeks to make the best possible use of the great potential of its 14,000 annually autopsies Death Verification Service of Sao Paulo. Although it seems logical that the increased capacity of imaging techniques to observe biological alterations results in more reliable correlation, validations are, in general, conceptually performed on a daily basis of equipment use, based on assumptions, rather than in structured clinical/histological/imaging correlation studies. However, in spite of their several scientific contributions, the volume of studies post-mortem is small, as it is difficult to obtain specimens on a routine basis. The present proposal overarching goal is to use this new imaging facility to explore two important topics: (a) the concept of minimally invasive autopsy as an alternative to increase the number of autopsies, to understand diseases processes and to evaluate clinical diagnosis and treatment; and (b) the role of autopsy to investigate the effects of urban environment in determining human disease. (AU)

Articles published in Agência FAPESP about the research grant
Air pollution affects tree growth in São Paulo 
Trees reveal the evolution of environmental pollution 
Advanced imaging facility unveiled at the University of São Paulo 
Matéria(s) publicada(s) em Outras Mídias:
Air pollution affects tree growth in Sao Paulo 
Air Pollution Affects Tree Growth in Sao Paulo – Eurasia Review 
Air Pollution Affects Tree Growth in Sao Paulo – Eurasia Review 
Air Pollution Affects Tree Growth in Sao Paulo – Eurasia Review 
Air Pollution Affects Tree Growth in Sao Paulo – Eurasia Review 
Air Pollution Affects Tree Growth in Sao Paulo – Eurasia Review 
Air Pollution Affects Tree Growth in Sao Paulo – Eurasia Review 
Air Pollution Affects Tree Growth in Sao Paulo – Eurasia Review 
Air Pollution Affects Tree Growth in Sao Paulo – Eurasia Review 
Air pollution affects tree growth in São Paulo 
Air pollution affects tree growth in São Paulo 
Air pollution affects tree growth in São Paulo 
Air pollution affects tree growth in Sao Paulo 
Air pollution affects tree growth in São Paulo 
Air pollution affects tree growth in São Paulo 
Poluição do ar afeta o crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 
Poluição do ar afeta crescimento de árvores em São Paulo 

Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOCOSSELLI, GIULIANO MASELLI; DE CAMARGO, EVELYN PEREIRA; LOPES MOREIRA, TIANA CARLA; TODESCO, ENZO; ANDRADE, MARIA DE FATIMA; SALDIVA DE ANDRE, CARMEN DIVA; DE ANDRE, PAULO AFONSO; SINGER, JULIO M.; FERREIRA, LUCIANA SCHWANDNER; NASCIMENTO SALDIVA, PAULO HILARIO; BUCKERIDGE, MARCOS SILVEIRA. The role of air pollution and climate on the growth of urban trees. Science of The Total Environment, v. 666, p. 652-661, MAY 20 2019. Web of Science Citations: 0.
SINGER, JULIO M.; ROCHA, FRANCISCO M. M.; ANDRE, CARMEN D. S.; ZERBINI, TALITA. Fitting mixed models to messy longitudinal data: A case study involving estimation of post mortem intervals. BRAZILIAN JOURNAL OF PROBABILITY AND STATISTICS, v. 33, n. 1, p. 161-183, FEB 2019. Web of Science Citations: 0.
LOCOSSELLI, GIULIANO MASELLI; CHACON-MADRID, KATHERINE; ZEZZI ARRUDA, MARCO AURELIO; DE CAMARGO, EVELYN PEREIRA; LOPES MOREIRA, TIANA CARLA; SALDIVA DE ANDRE, CARMEN DIVA; DE ANDRE, PAULO AFONSO; SINGER, JULIO M.; NASCIMENTO SALDIVA, PAULO HILARIO; BUCKERIDGE, MARCOS SILVEIRA. Tree rings reveal the reduction of Cd, Cu, Ni and Pb pollution in the central region of Sao Paulo, Brazil. Environmental Pollution, v. 242, n. A, p. 320-328, NOV 2018. Web of Science Citations: 1.
MOREIRA, TIANA C. L.; AMATO-LOURENCO, LUIS F.; DA SILVA, GISELA T.; SALDIVA DE ANDRE, CARMEN D.; DE ANDRE, PAULO A.; BARROZO, LIGIA V.; SINGER, JULIO M.; SALDIVA, PAULO H. N.; SAIKI, MITIKO; LOCOSSELLI, GIULIANO M. The Use of Tree Barks to Monitor Traffic Related Air Pollution: A Case Study in Sao Paulo-Brazil. FRONTIERS IN ENVIRONMENTAL SCIENCE, v. 6, JUL 13 2018. Web of Science Citations: 3.
PASQUA, LEONARDO ALVES; DAMASCENO, MAYARA VIEIRA; CRUZ, RAMON; MATSUDA, MONIQUE; MARTINS, MARCO GARCIA; LIMA-SILVA, ADRIANO EDUARDO; MARQUEZINI, MONICA; NASCIMENTO SALDIVA, PAULO HILARIO; BERTUZZI, ROMULO. Exercising in Air Pollution: The Cleanest versus Dirtiest Cities Challenge. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 15, n. 7 JUL 2018. Web of Science Citations: 0.
DE LIMA TAGA, MARCEL F.; SINGER, JULIO M. Simple linear regression with interval censored dependent and independent variables. STATISTICAL METHODS IN MEDICAL RESEARCH, v. 27, n. 1, p. 198-207, JAN 2018. Web of Science Citations: 0.
ZERBINI, TALITA; PERCINIO GIANVECCHIO, VICTOR ALEXANDRE; REGINA, DAMARIS; TSUJIMOTO, TAMY; RITTER, VICTOR; SINGER, JULIO M. Suicides by hanging and its association with meteorological conditions in Sao Paulo. JOURNAL OF FORENSIC AND LEGAL MEDICINE, v. 53, p. 22-24, JAN 2018. Web of Science Citations: 1.
ROCHA, FRANCISCO M. M.; SINGER, JULIO M. Selection of terms in random coefficient regression models. Journal of Applied Statistics, v. 45, n. 2, p. 225-242, 2018. Web of Science Citations: 1.
LOCOSSELLI, GIULIANO MASELLI; BUCKERIDGE, MARCOS SILVEIRA. Dendrobiochemistry, a missing link to further understand carbon allocation during growth and decline of trees. TREES-STRUCTURE AND FUNCTION, v. 31, n. 6, p. 1745-1758, DEC 2017. Web of Science Citations: 6.
ZACCARELLI-MARINO, MARIA ANGELA; SALDIVA ANDRE, CARMEN DIVA; SINGER, JULIO M. Overt Primary Hypothyroidism in an Industrial Area in Sao Paulo, Brazil: The Impact of Public Disclosure. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 13, n. 11 NOV 2016. Web of Science Citations: 1.

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