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The use of modern autopsy techniques to investigate human diseases (MODAU)

Grant number: 13/21728-2
Support type:Research Projects - Thematic Grants
Duration: November 01, 2014 - October 31, 2019
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal researcher:Paulo Hilário Nascimento Saldiva
Grantee:Paulo Hilário Nascimento Saldiva
Home Institution: Instituto de Estudos Avançados (IEA). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Pesquisadores principais:
( Últimos )
Carlos Augusto Gonçalves Pasqualucci ; Edson Amaro Junior ; Elaine Maria Frade Costa ; Gregório Cardoso Tápias Ceccantini ; Julio da Motta Singer ; Ligia Vizeu Barrozo ; Luiz Fernando Ferraz da Silva ; Marcos Silveira Buckeridge ; Marisa Dolhnikoff ; Mitiko Saiki ; Pérola de Castro Vasconcellos ; Thais Mauad
Pesquisadores principais:
( Antigos )
João Eduardo Ferreira ; Maria de Fátima Andrade
Assoc. researchers:Alexandre Valotta da Silva ; Aline Pivetta Cora ; Ana Luiza de Souza Bierrenbach ; Ana Paula Cremasco Takano ; Antonio Carlos Pedroso de Lima ; Carmen Diva Saldiva de André ; Catia Martinez Minto ; Claudia da Costa Leite ; Claudia Kimie Suemoto ; Gisela Tunes da Silva ; Henrique César Santejo Silveira ; José Marcelo Farfel ; Lea Tenenholz Grinberg ; Leila Antonangelo ; Lucia Maria Machado Bógus ; Lucia Pereira Barroso ; Luiz Alberto Amador Pereira ; Maria de Fátima Andrade ; Maria Lucia Bueno Garcia ; Mariana Matera Veras ; Marina Jorge de Miranda ; Milton de Arruda Martins ; Mônica Valeria Marquezini ; Nelson Ithiro Tanaka ; Paulo Afonso de André ; Paulo Justiniano Ribeiro Junior ; Paulo Sergio Panse Silveira ; Regina Maura de Miranda ; Reinaldo Paul Pérez Machado ; Renata Elaine Paraizo Leite ; Renata Eloah de Lucena Ferretti-Rebustini ; Ricardo Nitrini ; Ruy de Camargo Pires Neto ; Silvia Helena Gelás Lage ; Silvia Regina Dias Medici Saldiva ; Suzana Pasternak ; Tiana Carla Lopes Moreira ; William Nilson de Amorim ; Wilson Jacob Filho
Associated grant(s):19/07519-8 - 62nd ISI World Statistics Congress 2019, AR.EXT
19/02898-0 - Airborne microplastics: detection in environmental air samples, lung tissue and effects on cultured lung epithelial cells, AP.R SPRINT
16/50192-1 - Evaluation of new alternatives to increase the accuracy of the determination of cause of death: a public health approach, AP.R SPRINT
15/50081-2 - Achieving sustainable food production and irrigation in São Paulo and Melbourne, AP.R SPRINT
Associated scholarship(s):19/03397-5 - Identification and physical-chemical characterization of environmental microplastics in the atmosphere and in human lung tissues, BP.PD
18/24085-9 - Expression of RAGE in pulmonary tissue of patients diagnosed with sepsis and acute respiratory distress syndrome, BP.IC
17/06670-9 - Co-benefits of the reduction of atmospheric pollution from the transport of passengers in São Paulo: an integrated economic evaluation of health impacts using different vehicle emission scenarios., BP.PD
+ associated scholarships 17/10515-9 - Biomonitoring using tree bark and its correlation with particulate matter, BP.IC
17/10514-2 - Green areas as filters of atmospheric pollution of vehicular emissions in the city of São Paulo, BP.IC
17/10544-9 - Dendrochronology of Cedrela fissilis from an urban park in São Paulo, BP.IC
17/09486-4 - Digital atlas of pathology, BP.IC
16/23129-7 - Impact of long-term exposure to air pollution on myocardium ageing, BP.PD
16/23339-1 - Molecular characterization and occurrence of organic compounds in gaseous and particulate phase in atmospheric particulate matter collected in Petrochemical Industry of Capuava (SP), BP.DD
16/09411-1 - Spatio-temporal model for predicting the concentration of fine particulate matter (PM 2.5) in metropolitan area of São Paulo, BP.DR
16/22793-0 - Alzheimer's Disease in the olfactory epithelium: correlation with the environment, BP.PD
16/15989-6 - Green spaces and health: the impact of green spaces on the population of the Metropolitan Area of São Paulo, BP.PD
16/17936-7 - Secondary aerosol: precursors and contribution to the atmospheric particulate matter, BP.PD
16/03461-7 - Comparison of minimally invasive autopsy and conventional autopsy for post-mortem malignant neoplasm diagnosis, BP.PD
15/25511-3 - Climate and pollution reconstruction based on urban tree-rings growth records, BP.PD
15/03932-7 - MetroHealth Data Warehouse: Multidimensional Data Visualization and Data Extract, BP.TT
15/02770-3 - The use of semi-automated and automated strategies for co registration and correlation between radiographic and pathologic image analysis in the central nervous system - a feasibility study, BE.PQ
15/01798-1 - MetroHealth Data Warehouse: Conceptual Modeling and Implementation, BP.TT - associated scholarships

Abstract

Since ancient times, passing through the first known anatomic studies in the Middle Ages to the use of modern molecular techniques for the study of physiopathological processes, autopsy has shown to be a very rich source of material and inspiration for the advancement of scientific knowledge. Although a wide range of imaging techniques have emerged, several studies have shown that the autopsy remains crucial for: the complete assessment of the disease process, the assessment of new pathologies and quality control of the medical service. Autopsy also allows for the development of concomitant and associated projects in different areas due to the abundance of material. The School of Medicine of the University of Sao Paulo (FMUSP) seeks to make the best possible use of the great potential of its 14,000 annually autopsies Death Verification Service of Sao Paulo. Although it seems logical that the increased capacity of imaging techniques to observe biological alterations results in more reliable correlation, validations are, in general, conceptually performed on a daily basis of equipment use, based on assumptions, rather than in structured clinical/histological/imaging correlation studies. However, in spite of their several scientific contributions, the volume of studies post-mortem is small, as it is difficult to obtain specimens on a routine basis. The present proposal overarching goal is to use this new imaging facility to explore two important topics: (a) the concept of minimally invasive autopsy as an alternative to increase the number of autopsies, to understand diseases processes and to evaluate clinical diagnosis and treatment; and (b) the role of autopsy to investigate the effects of urban environment in determining human disease. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Cuando los niños se enferman gravemente 
Severe illness in children 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (24)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOCOSSELLI, GIULIANO MASELLI; BRIENEN, ROEL J. W.; LEITE, MELINA DE SOUZA; GLOOR, MANUEL; KROTTENTHALER, STEFAN; DE OLIVEIRA, ALEXANDRE A.; BARICHIVICH, JONATHAN; ANHUF, DIETER; CECCANTINI, GREGORIO; SCHONGART, JOCHEN; BUCKERIDGE, MARCOS. Global tree-ring analysis reveals rapid decrease in tropical tree longevity with temperature. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 117, n. 52, p. 33358-33364, DEC 29 2020. Web of Science Citations: 0.
BAILEY, ADAM L.; KANG, I, LIANG-; FRANCISCO DE ASSIS BARROS D'ELIA ZANELLA, LUIZ GONZAGA; SILVEIRA, CASSIA G. T.; HO, YEH-LI; FOQUET, LANDER; BIAL, GREG; MCCUNE, BROC T.; DUARTE-NETO, AMARO NUNES; THOMAS, ARCHANA; RAUE, HANS-PETER; BYRNES, KATHLEEN; KALLAS, ESPER G.; SLIFKA, MARK K.; DIAMOND, MICHAEL S. Consumptive coagulopathy of severe yellow fever occurs independently of hepatocellular tropism and massive hepatic injury. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 117, n. 51, p. 32648-32656, DEC 22 2020. Web of Science Citations: 0.
ALVES, NILMARA DE OLIVEIRA; PEREIRA, GUILHERME MARTINS; DI DOMENICO, MARLISE; COSTANZO, GIOVANNA; BENEVENUTO, SARAH; FONOFF, ADRIANA M. DE OLIVEIRA; XAVIER COSTA, NATALIA DE SOUZA; RIBEIRO, JR., GABRIEL; KAJITANI, GUSTAVO SATORU; MORENO, NATALIA CESTARI; FOTORAN, WESLEY; TORRES, JANAINA IANNICELLI; DE ANDRADE, JAILSON BITTENCOURT; VERAS, MARIANA MATERA; ARTAXO, PAULO; MARTINS MENCK, CARLOS FREDERICO; VASCONCELLOS, PEROLA DE CASTRO; SALDIVA, PAULO. Inflammation response, oxidative stress and DNA damage caused by urban air pollution exposure increase in the lack of DNA repair XPC protein. Environment International, v. 145, DEC 2020. Web of Science Citations: 0.
LOCOSSELLI, GIULIANO MASELLI; LOPES MOREIRA, TIANA CARLA; CHACON-MADRIZ, KATHERINE; ZEZZI ARRUDA, MARCO AURELIO; DE CAMARGO, EVELYN PEREIRA; KAMIGAUTI, LEONARDO YOSHIAKI; FERREIRA DA TRINDADE, RICARDO IVAN; ANDRADE, MARIA DE FATIMA; SALDIVA DE ANDRE, CARMEN DIVA; DE ANDRE, PAULO AFONSO; SINGER, JULIO M.; SAIKI, MITIKO; ZACCARELLI-MARINO, MARIA ANGELA; NASCIMENTO SALDIVA, PAULO HILARIO; BUCKERIDGE, MARCOS SILVEIRA. Spatial-temporal variability of metal pollution across an industrial district, evidencing the environmental inequality in Sao Paulo. Environmental Pollution, v. 263, n. A AUG 2020. Web of Science Citations: 0.
CORDER, RODRIGO M.; DE LIMA, ANTONIO C. P.; KHOURY, DAVID S.; DOCKEN, STEFFEN S.; DAVENPORT, MILES P.; FERREIRA, MARCELO U. Quantifying and preventingPlasmodium vivaxrecurrences in primaquine-untreated pregnant women: An observational and modeling study in Brazil. PLoS Neglected Tropical Diseases, v. 14, n. 7 JUL 2020. Web of Science Citations: 0.
DI DOMENICO, MARLISE; DE MENEZES BENEVENUTO, SARAH GOMES; TOMASINI, PAULA PELLENZ; YARIWAKE, VICTOR YUJI; ALVES, NILMARA DE OLIVEIRA; RAHMEIER, FRANCINE LUCIANO; FERNANDES, MARILDA DA CRUZ; MOURA, DINARA JAQUELINE; NASCIMENTO SALDIVA, PAULO HILARIO; VERAS, MARIANA MATERA. Concentrated ambient fine particulate matter (PM2.5) exposure induce brain damage in pre and postnatal exposed mice. NeuroToxicology, v. 79, p. 127-141, JUL 2020. Web of Science Citations: 0.
BARROZO, LIGIA VIZEU; FORNACIALI, MICHEL; SALDIVA DE ANDRE, CARMEN DIVA; ZIMEO MORAIS, GUILHERME AUGUSTO; MANSUR, GISELLE; CABRAL-MIRANDA, WILLIAM; DE MIRANDA, MARINA JORGE; SATO, JOAO RICARDO; AMARO JUNIOR, EDSON. GeoSES: A socioeconomic index for health and social research in Brazil. PLoS One, v. 15, n. 4 APR 29 2020. Web of Science Citations: 0.
MOREIRA, TIANA C. L.; POLIZEL, JEFFERSON L.; SANTOS, ITAMAR DE SOUZA; FILHO, DEMOSTENES F. SILVA; BENSENOR, ISABELA; LOTUFO, PAULO A.; MAUAD, THAIS. Green Spaces, Land Cover, Street Trees and Hypertension in the Megacity of Sao Paulo. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 17, n. 3 FEB 1 2020. Web of Science Citations: 0.
DOS SANTOS, NATHALIA VILLA; ZILLI VIEIRA, CAROLINA LETICIA; NASCIMENTO SALDIVA, PAULO HILARIO; MAZZILLI, BARBARA PACI; SAIKI, MITIKO; SAUEIA, CATIA HELOISA; SALDIVA DE ANDRE, CARMEN DIVA; JUSTO, LISIE TOCCI; NISTI, MARCELO BESSA; KOUTRAKIS, PETROS. Levels of Polonium-210 in brain and pulmonary tissues: Preliminary study in autopsies conducted in the city of Sao Paulo, Brazil. SCIENTIFIC REPORTS, v. 10, n. 1 JAN 13 2020. Web of Science Citations: 0.
CUNHA, MARIELTON DOS PASSOS; DUARTE-NETO, AMARO NUNES; POUR, SHAHAB ZAKI; ORTIZ-BAEZ, AYDA SUSANA; CERNY, JIRI; DE SOUZA PEREIRA, BARBARA BRITO; BRACONI, CARLA TORRES; HO, YEH-LI; PERONDI, BEATRIZ; SZTAJNBOK, JAQUES; FERREIRA ALVES, VENANCIO AVANCINI; DOLHNIKOFF, MARISA; HOLMES, EDWARD C.; NASCIMENTO SALDIVA, PAULO HILARIO; DE ANDRADE ZANOTTO, PAOLO MARINHO. Origin of the Sao Paulo Yellow Fever epidemic of 2017-2018 revealed through molecular epidemiological analysis of fatal cases. SCIENTIFIC REPORTS, v. 9, DEC 31 2019. Web of Science Citations: 0.
PEREIRA, GUILHERME MARTINS; DA SILVA CAUMO, SOFIA ELLEN; MOTA NASCIMENTO, EMERSON QUEIROZ; PARRA, YENDRY JOMOLCA; VASCONCELLOS, PEROLA DE CASTRO. Polycyclic aromatic hydrocarbons in tree barks, gaseous and particulate phase samples collected near an industrial complex in Sao Paulo (Brazil). Chemosphere, v. 237, DEC 2019. Web of Science Citations: 0.
CREMASCO TAKANO, ANA PAULA; JUSTO, LISIE TOCCI; DOS SANTOS, NATHALIA VILLA; MARQUEZINI, MONICA VALERIA; DE ANDRE, PAULO AFONSO; MONTEIRO DA ROCHA, FRANCISCO MARCELO; PASQUALUCCI, CARLOS AUGUSTO; BARROZO, LIGIA VIZEU; SINGER, JULIO M.; SALDIVA DE ANDRE, CARMEN DIVA; NASCIMENTO SALDIVA, PAULO HILARIO; VERAS, MARIANA MATERA. Pleural anthracosis as an indicator of lifetime exposure to urban air pollution: An autopsy-based study in Sao Paulo. Environmental Research, v. 173, p. 23-32, JUN 2019. Web of Science Citations: 3.
GODOY-VEIGA, MILENA; SLOTTA, FRANZISKA; ALECIO, PAULA CHRISTIANI; CECCANTINI, GREGORIO; BUCKERIDGE, MARCOS SILVEIRA; LOCOSSELLI, GIULIANO MASELLI. Improved tree-ring visualization using autofluorescence. DENDROCHRONOLOGIA, v. 55, p. 33-42, JUN 2019. Web of Science Citations: 0.
LOCOSSELLI, GIULIANO MASELLI; DE CAMARGO, EVELYN PEREIRA; LOPES MOREIRA, TIANA CARLA; TODESCO, ENZO; ANDRADE, MARIA DE FATIMA; SALDIVA DE ANDRE, CARMEN DIVA; DE ANDRE, PAULO AFONSO; SINGER, JULIO M.; FERREIRA, LUCIANA SCHWANDNER; NASCIMENTO SALDIVA, PAULO HILARIO; BUCKERIDGE, MARCOS SILVEIRA. The role of air pollution and climate on the growth of urban trees. Science of The Total Environment, v. 666, p. 652-661, MAY 20 2019. Web of Science Citations: 4.
DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; LIMA, FLAVIA AFONSO; BANDEIRA, CARLA LETICIA; MURILLO, OSCAR; COSTA, DOUGLAS DE SOUSA; MACHADO PEIXOTO, ERIKA PAULA; CUNHA, MARIELTON DOS PASSOS; DE ANDRADE ZANOTTO, PAOLO MARINHO; BEVILACQUA, ESTELA; GRIGOLIN GRISOTTO, MARCOS AUGUSTO; PEDROSO DE LIMA, ANTONIO CARLOS; SINGER, JULIO DA MOTTA; CAMPINO, SUSANA; CLARK, TAANE GREGORY; EPIPHANIO, SABRINA; GONCALVES, LIGIA ANTUNES; FARIAS MARINHO, CLAUDIO ROMERO. Association of Malaria Infection During Pregnancy With Head Circumference of Newborns in the Brazilian Amazon. JAMA NETWORK OPEN, v. 2, n. 5 MAY 2019. Web of Science Citations: 1.
SINGER, JULIO M.; ROCHA, FRANCISCO M. M.; ANDRE, CARMEN D. S.; ZERBINI, TALITA. Fitting mixed models to messy longitudinal data: A case study involving estimation of post mortem intervals. BRAZILIAN JOURNAL OF PROBABILITY AND STATISTICS, v. 33, n. 1, p. 161-183, FEB 2019. Web of Science Citations: 0.
LOCOSSELLI, GIULIANO MASELLI; CHACON-MADRID, KATHERINE; ZEZZI ARRUDA, MARCO AURELIO; DE CAMARGO, EVELYN PEREIRA; LOPES MOREIRA, TIANA CARLA; SALDIVA DE ANDRE, CARMEN DIVA; DE ANDRE, PAULO AFONSO; SINGER, JULIO M.; NASCIMENTO SALDIVA, PAULO HILARIO; BUCKERIDGE, MARCOS SILVEIRA. Tree rings reveal the reduction of Cd, Cu, Ni and Pb pollution in the central region of Sao Paulo, Brazil. Environmental Pollution, v. 242, n. A, p. 320-328, NOV 2018. Web of Science Citations: 4.
MOREIRA, TIANA C. L.; AMATO-LOURENCO, LUIS F.; DA SILVA, GISELA T.; SALDIVA DE ANDRE, CARMEN D.; DE ANDRE, PAULO A.; BARROZO, LIGIA V.; SINGER, JULIO M.; SALDIVA, PAULO H. N.; SAIKI, MITIKO; LOCOSSELLI, GIULIANO M. The Use of Tree Barks to Monitor Traffic Related Air Pollution: A Case Study in Sao Paulo-Brazil. FRONTIERS IN ENVIRONMENTAL SCIENCE, v. 6, JUL 13 2018. Web of Science Citations: 4.
PASQUA, LEONARDO ALVES; DAMASCENO, MAYARA VIEIRA; CRUZ, RAMON; MATSUDA, MONIQUE; MARTINS, MARCO GARCIA; LIMA-SILVA, ADRIANO EDUARDO; MARQUEZINI, MONICA; NASCIMENTO SALDIVA, PAULO HILARIO; BERTUZZI, ROMULO. Exercising in Air Pollution: The Cleanest versus Dirtiest Cities Challenge. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 15, n. 7 JUL 2018. Web of Science Citations: 2.
DE LIMA TAGA, MARCEL F.; SINGER, JULIO M. Simple linear regression with interval censored dependent and independent variables. STATISTICAL METHODS IN MEDICAL RESEARCH, v. 27, n. 1, p. 198-207, JAN 2018. Web of Science Citations: 0.
ZERBINI, TALITA; PERCINIO GIANVECCHIO, VICTOR ALEXANDRE; REGINA, DAMARIS; TSUJIMOTO, TAMY; RITTER, VICTOR; SINGER, JULIO M. Suicides by hanging and its association with meteorological conditions in Sao Paulo. JOURNAL OF FORENSIC AND LEGAL MEDICINE, v. 53, p. 22-24, JAN 2018. Web of Science Citations: 1.
ROCHA, FRANCISCO M. M.; SINGER, JULIO M. Selection of terms in random coefficient regression models. Journal of Applied Statistics, v. 45, n. 2, p. 225-242, 2018. Web of Science Citations: 2.
LOCOSSELLI, GIULIANO MASELLI; BUCKERIDGE, MARCOS SILVEIRA. Dendrobiochemistry, a missing link to further understand carbon allocation during growth and decline of trees. TREES-STRUCTURE AND FUNCTION, v. 31, n. 6, p. 1745-1758, DEC 2017. Web of Science Citations: 12.
ZACCARELLI-MARINO, MARIA ANGELA; SALDIVA ANDRE, CARMEN DIVA; SINGER, JULIO M. Overt Primary Hypothyroidism in an Industrial Area in Sao Paulo, Brazil: The Impact of Public Disclosure. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 13, n. 11 NOV 2016. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.