Insights into the cellular responses to hypoxia in filamentous fungi

Autor(es)

Hillmann, Falk ^{[1, 2]} ; Shekhova, Elena ^{[1, 2]} ; Kniemeyer, Olaf ^{[1, 2, 3]}

Afiliação do(s) autor(es)

^[1] HKI, Leibniz Inst Nat Product Res & Infect Biol, Dept Mol & Appl Microbiol, D-07743 Jena - Germany

^[2] Univ Jena, Inst Microbiol, D-07743 Jena - Germany

^[3] Univ Hosp, Integrated Res & Treatment Ctr, CSCC, D-07747 Jena - Germany

• Tipo de documento: Artigo Científico
• Fonte: CURRENT GENETICS; v. 61, n. 3, p. 441-455, AUG 2015.
• Citações Web of Science: 16

Resumo

Most eukaryotes require molecular oxygen for growth. In general, oxygen is the terminal electron acceptor of the respiratory chain and represents an important substrate for the biosynthesis of cellular compounds. However, in their natural environment, such as soil, and also during the infection, filamentous fungi are confronted with low levels of atmospheric oxygen. Transcriptome and proteome studies on the hypoxic response of filamentous fungi revealed significant alteration of the gene expression and protein synthesis upon hypoxia. These analyses discovered not only common but also species-specific responses to hypoxia with regard to NAD(+) regeneration systems and other metabolic pathways. A surprising outcome was that the induction of oxidative and nitrosative stress defenses during oxygen limitation represents a general trait of adaptation to hypoxia in many fungi. The interplay of these different stress responses is poorly understood, but recent studies have shown that adaptation to hypoxia contributes to virulence of pathogenic fungi. In this review, results on metabolic changes of filamentous fungi during adaptation to hypoxia are summarized and discussed. (AU)

• Processo FAPESP: 14/01229-4 - International Symposium on Fungal Stress - ISFUS
• Beneficiário: Drauzio Eduardo Naretto Rangel
• Modalidade de apoio: Auxílio Organização - Reunião Científica