Lowered paraoxonase 1 (PON1) activity is associated with increased cytokine levels in drug naive first episode psychosis

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Brinholi, Francis Fregonesi ^[1] ; Noto, Cristiano ^{[2, 3]} ; Maesa'd, Michael ^{[4, 1]} ; Bonifacio, Kamila Landucci ^[1] ; Brietzke, Elisa ^[2] ; Ota, Vanessa Kiyomi ^[2] ; Gadelha, Ary ^[2] ; Cordeiro, Quirino ^{[2, 3]} ; Belangero, Sintia Iole ^[2] ; Bressan, Rodrigo Affonseca ^[2] ; Vargas, Heber Odebrecht ^[1] ; Higachi, Luciana ^[1] ; de Farias, Carine Coneglian ^[1] ; Moreira, Estefania Gastaldello ^[1] ; Barbosa, Decio Sabbatini ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Londrina, Graduat Program Hlth Sci, Londrina, PR - Brazil

^[2] Univ Fed Sao Paulo, LiNC Interdisciplinary Lab Clin Neurosci, Sao Paulo, SP - Brazil

^[3] FCMSCSP, Episode Psychosis Program 1, Sao Paulo, SP - Brazil

^[4] Chulalongkorn Univ, Dept Psychiat, Bangkok - Thailand

• Tipo de documento: Artigo Científico
• Fonte: SCHIZOPHRENIA RESEARCH; v. 166, n. 1-3, p. 225-230, AUG 2015.
• Citações Web of Science: 9

Resumo

Background: Activated immune-inflammatory pathways play an important role in the pathophysiology of schizophrenia. Paraoxonase 1 (PON1) activity is inversely associated with inflammatory responses in numerous clinical conditions. The aims of this study were to delineate serum arylesterase PON1 activity in drug-naive first episode psychosis (PEP) patients and a healthy control group, and to assess whether there are inverse relationships between PON1 activity and cytokine levels. Methods: A total of 51 drug-naive FEP patients and 61 healthy controls were enrolled in this study. Levels of interleukin (IL)-4, IL-10, IL-6, tumor necrosis factor (TNF)-alpha and activity of PON1 were quantified. Results: Compared to healthy controls, FEP patients showed lower serum PON1 activity and higher levels of IL-4, IL-10 and TNF-alpha. A significant inverse relationship between PON1 activity and IL-4, IL-6 and IL-10 levels was detected, but not for TNF-alpha. Subjects with very low PON1 activity (25th quartile) presented significantly higher levels of IL-6, IL-10 and IL-4 than those with higher PON1 activity (75th quartile). Conclusion: The present study provides evidence that FEP is characterized by an inverse relationship between lowered activity of the anti-inflammatory/antioxidant enzyme PON1 and increased cytokine levels, including IL-6, IL-4 and IL-10 It is hypothesized that lowered PON1 activity may play a role in the immune-inflammatory response that accompanies PEP and that increased cytokine levels may further modulate PON1 activity. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 11/50740-5 - Prevenção na esquizofrenia e no transtorno bipolar da neurociência à comunidade: uma plataforma multifásica, multimodal e translacional para investigação e intervenção
• Beneficiário: Rodrigo Affonseca Bressan
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 10/19176-3 - Análise de expressão gênica e metilação de DNA de pacientes em primeiro episódio psicótico virgens de tratamento
• Beneficiário: Vanessa Kiyomi Ota Kuniyoshi
• Modalidade de apoio: Bolsas no Brasil - Doutorado