Lomefloxacin Degradation: Antimicrobial Activity, Toxicity and Byproducts

Autor(es)

de Oliveira, Amanda M. D. ^[1] ; Maniero, Milena G. ^[1] ; Guimaraes, Jose R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Sch Civil Engn Architecture & Urban Design, BR-13083852 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ADVANCED OXIDATION TECHNOLOGIES; v. 18, n. 2, p. 211-220, JUL 31 2015.
• Citações Web of Science: 6

Resumo

Lomefloxacin (LOM) is an important antimicrobial drug. It has been detected in aqueous matrices in several countries. Its continuous introduction into the environment is a potential risk to aquatic and terrestrial organisms. The aim of this study was to evaluate the degradation of LOM by photolysis, peroxidation, and peroxidation assisted by ultraviolet radiation; moreover, the residual antimicrobial activity, the toxicity, and the byproducts formed during degradation processes were evaluated. Peroxidation was inefficient for LOM degradation and was not able to reduce antimicrobial activity. Both photolysis and UV/H2O2 were able to degrade more than 95% of LOM in 60 min (radiation dose of 5267 mJ cm(-2)). However, toxicity increased while these processes were being applied. For all processes evaluated, antimicrobial activity was still detected in the solution after 60 min of testing. Four byproducts were identified: m/z 332, 336, 348, and 350. (AU)

• Processo FAPESP: 13/07817-2 - Degradação de sulfonamidas e tetraciclinas por UV/H2O2 e O3: avaliação da atividade antimicrobiana e da toxicidade
• Beneficiário: Milena Guedes Maniero Ferreira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/09543-7 - Resíduos de medicamentos veterinários no ambiente
• Beneficiário: Susanne Rath
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/04656-8 - Degradação de fármacos por peroxidação assistida por radiação ultravioleta e ozonização: atividade antimicrobiana e toxicidade
• Beneficiário: José Roberto Guimarães
• Modalidade de apoio: Auxílio à Pesquisa - Regular