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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lomefloxacin Degradation: Antimicrobial Activity, Toxicity and Byproducts

de Oliveira, Amanda M. D. [1] ; Maniero, Milena G. [1] ; Guimaraes, Jose R. [1]
Total Authors: 3
[1] Univ Estadual Campinas, UNICAMP, Sch Civil Engn Architecture & Urban Design, BR-13083852 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF ADVANCED OXIDATION TECHNOLOGIES; v. 18, n. 2, p. 211-220, JUL 31 2015.
Web of Science Citations: 6

Lomefloxacin (LOM) is an important antimicrobial drug. It has been detected in aqueous matrices in several countries. Its continuous introduction into the environment is a potential risk to aquatic and terrestrial organisms. The aim of this study was to evaluate the degradation of LOM by photolysis, peroxidation, and peroxidation assisted by ultraviolet radiation; moreover, the residual antimicrobial activity, the toxicity, and the byproducts formed during degradation processes were evaluated. Peroxidation was inefficient for LOM degradation and was not able to reduce antimicrobial activity. Both photolysis and UV/H2O2 were able to degrade more than 95% of LOM in 60 min (radiation dose of 5267 mJ cm(-2)). However, toxicity increased while these processes were being applied. For all processes evaluated, antimicrobial activity was still detected in the solution after 60 min of testing. Four byproducts were identified: m/z 332, 336, 348, and 350. (AU)

FAPESP's process: 13/07817-2 - Degradation of sulfonamides and tetraciclines by UV/H2O2 and O3: evaluation of antimicrobial activity and toxicity
Grantee:Milena Guedes Maniero Ferreira
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/09543-7 - Residues of veterinary drugs in the environment
Grantee:Susanne Rath
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/04656-8 - Degradation of pharmaceuticals by peroxidation combined with ultraviolet radiation and ozonation: antimicrobial activity and toxicity
Grantee:José Roberto Guimarães
Support type: Regular Research Grants