Sulfonamide is a group of synthetic antimicrobials containing over 150 sulfas, which act on the nucleic acids of target microorganisms inhibiting their growth. Since 1982, they have been detected in water bodies from various countries such as the USA, France and China. Tetracycline is the second most common group of antibiotics in the world both in production volume and use; it is used to treat diseases in human beings and livestock. Most of the administered drugs are excreted via urine and/or feces. Therefore, these drugs are often found in wastewater treatment plants, natural waters and groundwater in the range of µg L-1 and ng L-1. Due to their constant introduction into the environment and their poor natural degradation in aqueous media, these pharmaceuticals are considered persistent and their presence in the environment may contribute to the development of resistant bacteria. Currently, there are few available studies evaluating the degradation of sulfaquinoxaline and doxycycline by ozonation and advanced oxidation processes. In the proposed study, it will be evaluated the efficiency of photolysis, peroxidation, peroxidation combined with ultraviolet radiation, and ozonation to degrade sulfaquinoxaline and doxycycline aqueous solutions and to reduce the antimicrobial activity and toxicity. Finally, the intermediates formed during the degradation processes will also be investigated and proposed.
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