Scholarship 13/07817-2 - Anti-infecciosos, Processos oxidativos avançados - BV FAPESP
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Degradation of sulfonamides and tetraciclines by UV/H2O2 and O3: evaluation of antimicrobial activity and toxicity

Grant number: 13/07817-2
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Start date until: November 01, 2013
End date until: October 31, 2017
Field of knowledge:Engineering - Sanitary Engineering - Water Supply and Wastewater Treatment
Principal Investigator:José Roberto Guimarães
Grantee:Milena Guedes Maniero Ferreira
Host Institution: Faculdade de Engenharia Civil, Arquitetura e Urbanismo (FEC). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/09543-7 - Residues of veterinary drugs in the environment, AP.TEM

Abstract

Sulfonamide is a group of synthetic antimicrobials containing over 150 sulfas, which act on the nucleic acids of target microorganisms inhibiting their growth. Since 1982, they have been detected in water bodies from various countries such as the USA, France and China. Tetracycline is the second most common group of antibiotics in the world both in production volume and use; it is used to treat diseases in human beings and livestock. Most of the administered drugs are excreted via urine and/or feces. Therefore, these drugs are often found in wastewater treatment plants, natural waters and groundwater in the range of µg L-1 and ng L-1. Due to their constant introduction into the environment and their poor natural degradation in aqueous media, these pharmaceuticals are considered persistent and their presence in the environment may contribute to the development of resistant bacteria. Currently, there are few available studies evaluating the degradation of sulfaquinoxaline and doxycycline by ozonation and advanced oxidation processes. In the proposed study, it will be evaluated the efficiency of photolysis, peroxidation, peroxidation combined with ultraviolet radiation, and ozonation to degrade sulfaquinoxaline and doxycycline aqueous solutions and to reduce the antimicrobial activity and toxicity. Finally, the intermediates formed during the degradation processes will also be investigated and proposed.

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Scientific publications (16)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GRACA, CATIA A. L.; MANIERO, MILENA GUEDES; DE ANDRADE, LIDIANE MARIA; GUIMARAES, JOSE ROBERTO; TEIXEIRA, ANTONIO CARLOS S. C.. Evaluation of amicarbazone toxicity removal through degradation processes based on hydroxyl and sulfate radicals. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING, v. 54, n. 11, . (13/09543-7, 13/07817-2, 13/50218-2, 13/04656-8)
TETZNER, NATALIA FERNANDA; MANIERO, MILENA GUEDES; RODRIGUES-SILVA, CAIO; RATH, SUSANNE. On-line solid phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry as a powerful technique for the determination of sulfonamide residues in soils. Journal of Chromatography A, v. 1452, p. 89-97, . (13/07817-2, 13/09543-7, 14/16622-3, 14/06201-0)
CAIO RODRIGUES-SILVA; MILENA G. MANIERO; MARCELA S. PERES; JOSÉ ROBERTO GUIMARÃES. Ocorrência e degradação de quinolonas por processos oxidativos avançados. Química Nova, v. 37, n. 5, p. 868-885, . (13/07817-2, 08/06470-0)
DE OLIVEIRA, AMANDA M. D.; MANIERO, MILENA G.; GUIMARAES, JOSE R.. Lomefloxacin Degradation: Antimicrobial Activity, Toxicity and Byproducts. JOURNAL OF ADVANCED OXIDATION TECHNOLOGIES, v. 18, n. 2, p. 211-220, . (13/07817-2, 13/09543-7, 13/04656-8)
URBANO, VANESSA RIBEIRO; PERES, MARCELA SOUZA; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Abatement and toxicity reduction of antimicrobials by UV/H2O2 process. Journal of Environmental Management, v. 193, p. 439-447, . (13/04656-8, 13/09543-7, 13/07817-2)
CAIANELO, MARLON; RODRIGUES-SILVA, CAIO; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Antimicrobial activity against Gram-positive and Gram-negative bacteria during gatifloxacin degradation by hydroxyl radicals. Environmental Science and Pollution Research, v. 24, n. 7, p. 6288-6298, . (14/16622-3, 14/06064-3, 13/09543-7, 13/04656-8, 13/07817-2, 14/06201-0)
RATH, SUSANNE; PEREIRA, LEANDRO ALVES; DAL BOSCO, SANDRA MARIA; MANIERO, MILENA GUEDES; FOSTIER, ANNE HELENE; GUIMARAES, JOSE ROBERTO. Fate of ivermectin in the terrestrial and aquatic environment: mobility, degradation, and toxicity towards Daphnia similis. Environmental Science and Pollution Research, v. 23, n. 6, p. 5654-5666, . (13/07817-2, 13/09543-7, 09/17470-4)
URBANO, VANESSA RIBEIRO; MANIERO, MILENA GUEDES; PEREZ-MOYA, MONTSERRAT; GUIMARAES, JOSE ROBERTO. Influence of pH and ozone dose on sulfaquinoxaline ozonation. Journal of Environmental Management, v. 195, p. 8-pg., . (14/06064-3, 13/04656-8, 13/09543-7, 14/06201-0, 13/07817-2)
GIRELI, GLENDA ARAUJO S.; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Influence of pH value on sulfonamide ozonation using caffeine as a contamination indicator. WATER SCIENCE AND TECHNOLOGY-WATER SUPPLY, v. 20, n. 2, p. 508-515, . (13/09543-7, 13/07817-2)
RIBEIRO URBANO, VANESSA; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO; DEL VALLE, LUIS J.; PEREZ-MOYA, MONTSERRAT. Sulfaquinoxaline Oxidation and Toxicity Reduction by Photo-Fenton Process. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 18, n. 3, . (13/09543-7, 13/04656-8, 13/07817-2)
SPINA-CRUZ, MYLENA; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Advanced oxidation processes on doxycycline degradation: monitoring of antimicrobial activity and toxicity. Environmental Science and Pollution Research, v. 26, n. 27, SI, p. 27604-27619, . (13/07817-2, 13/09543-7, 13/04656-8)
URBANO, VANESSA RIBEIRO; MANIERO, MILENA GUEDES; PEREZ-MOYA, MONTSERRAT; GUIMARAES, JOSE ROBERTO. Influence of pH and ozone dose on sulfaquinoxaline ozonation. Journal of Environmental Management, v. 195, n. 2, SI, p. 224-231, . (13/04656-8, 14/06201-0, 13/07817-2, 13/09543-7, 14/06064-3)
DUARTE DE OLIVEIRA, AMANDA MARCHI; MANIERO, MILENA GUEDES; RODRIGUES-SILVA, CAIO; GUIMARAES, JOSE ROBERTO. Antimicrobial activity and acute toxicity of ozonated lomefloxacin solution. Environmental Science and Pollution Research, v. 24, n. 7, p. 6252-6260, . (13/04656-8, 13/09543-7, 13/07817-2, 14/16622-3)
LIMA VENANCIO, WILSON AUGUSTO; RODRIGUES-SILVA, CAIO; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Photocatalytic removal of fluoroquinolones and their antimicrobial activity from water matrices at trace levels: a comparison of commercial TiO2 catalysts. WATER SCIENCE AND TECHNOLOGY, v. 78, n. 8, p. 1668-1678, . (14/06201-0, 13/07817-2, 13/09543-7, 14/16622-3, 14/06064-3)
PERES, M. S.; MANIERO, M. G.; GUIMARAES, J. R.. Photocatalytic degradation of ofloxacin and evaluation of the residual antimicrobial activity. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, v. 14, n. 3, p. 556-562, . (13/07817-2, 13/09543-7)
SPINA-CRUZ, MYLENA; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Advanced oxidation processes on doxycycline degradation: monitoring of antimicrobial activity and toxicity. Environmental Science and Pollution Research, v. 26, n. 27, p. 16-pg., . (13/04656-8, 13/07817-2, 13/09543-7)

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