Residues of veterinary drugs in the environment

• Grant number: 13/09543-7
• Support Opportunities: Research Projects - Thematic Grants
• Start date: May 01, 2014
• End date: April 30, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Susanne Rath
• Grantee: Susanne Rath
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Anne Helene Fostier ; Caio Alexandre Augusto Rodrigues da Silva ; José Roberto Guimarães ; Milena Guedes Maniero Ferreira
• Associated research grant(s): 14/06064-3 - Multi-User Equipment aproved in grant 2013/09543-7: ultra high performance liquid chromatography with photodiode array detector and Fluorescence Detector (UPLC-DAD-FLD), AP.EMU; 14/06201-0 - Multi-equipment aproved in grant 2013/09543-7: ultra high performance liquid chromatograph coupled to a photodiode array detector and tandem mass spectrometer (UPLC-DAD-MS/MS), AP.EMU
• Associated scholarship(s): 14/16995-4 - Dynamics of macrolide antimicrobials in soils, BP.PD; 14/16622-3 - Identification of intermediates formed during degradation of veterinary drugs by advanced oxidation processes, BP.PD; 13/25670-9 - Antiparasitic in Brazilian soils: study of sorption, desorption and degradation, BP.DR; 13/07817-2 - Degradation of sulfonamides and tetraciclines by UV/H2O2 and O3: evaluation of antimicrobial activity and toxicity, BP.PD

Abstract

Veterinary drugs have been widely used in animal production chain to ensure the health and welfare of animals. Undoubtedly, the use of veterinary drugs in agriculture, especially antimicrobials and antiparasitic drugs, has allowed increasing productivity and enhancing the competitiveness of nationally and internationally Brazilian agribusiness. Generally, the drugs administered to animals are not completely metabolized, and the are excreted via urine and / or faeces. Thus, large quantities of pharmaceuticals, metabolites and / or degradation products are discharged into the environment each year. The residues can accumulate in the soil and in plants, as well as be transported to water bodies. The presence of antimicrobials in the environment may impact terrestrial and aquatic organisms and lead to the development of resistant bacteria. In fact, little is known about the chronic effects of exposure to low concentrations of these residues into the environment. Studies of their presence, dynamics and toxicity in the environment are still scarce for many drugs and most of the studies are limited to the detection of drugs in water. In Brazil, it may be considered that such data for veterinary drugs are nonexistent. The present project aims to assess the occurrence, behavior and ecotoxicological effects of antimicrobial and antiparasitic veterinary drugs in the environment of the State of São Paulo, and establish methods to promote the degradation of these drugs in sewage water treatment, based on advanced oxidation processes. (AU)

Scientific publications

(45)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE OLIVEIRA NETO, ODILON FRANCA; ARENAS, ALEJANDRO YOPASA; FOSTIER, ANNE HELENE. Sorption of thiabendazole in sub-tropical Brazilian soils. Environmental Science and Pollution Research, v. 24, n. 19, SI, p. 16503-16512, JUL 2017. (13/09543-7, 09/17470-4)

URBANO, VANESSA RIBEIRO; MANIERO, MILENA GUEDES; PEREZ-MOYA, MONTSERRAT; GUIMARAES, JOSE ROBERTO. Influence of pH and ozone dose on sulfaquinoxaline ozonation. Journal of Environmental Management, v. 195, n. 2, SI, p. 224-231, JUN 15 2017. (13/04656-8, 14/06201-0, 13/07817-2, 13/09543-7, 14/06064-3)

GRACA, CATIA A. L.; FUGITA, LUCAS T. N.; DE VELOSA, ADRIANA CORREIA; TEIXEIRA, ANTONIO CARLOS S. C.. Amicarbazone degradation promoted by ZVI-activated persulfate: study of relevant variables for practical application. Environmental Science and Pollution Research, v. 25, n. 6, SI, p. 5474-5483, FEB 2018. (13/09543-7, 13/04656-8, 13/50218-2)

SPINA-CRUZ, MYLENA; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Advanced oxidation processes on doxycycline degradation: monitoring of antimicrobial activity and toxicity. Environmental Science and Pollution Research, v. 26, n. 27, SI, p. 27604-27619, SEP 2019. (13/07817-2, 13/09543-7, 13/04656-8)

PORTO, RAFAEL SILVEIRA; PINHEIRO, RAFAEL SILVIO BONILHA; RATH, SUSANNE. Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta. Environmental Science and Pollution Research, MAR 2020. (13/09543-7, 18/03571-2)

RAFAEL S. PORTO; SUSANNE RATH; SONIA C. N. QUEIROZ. Conyza canadensis: Green Extraction Method of Bioactive Compounds and Evaluation of Their Antifungal Activity. Journal of the Brazilian Chemical Society, v. 28, n. 5, p. 913-919, Maio 2017. (13/09543-7)

DIONISIO, ANDREZA CAMILOTTI; RATH, SUSANNE. Abamectin in soils: Analytical methods, kinetics, sorption and dissipation. Chemosphere, v. 151, p. 17-29, MAY 2016. (13/09543-7)

YOPASA-ARENAS, ALEJANDRO; FOSTIER, ANNE HELENE. Exposure of Brazilian soil and groundwater to pollution by coccidiostats and antimicrobial agents used as growth promoters. Science of The Total Environment, v. 644, p. 112-121, DEC 10 2018. (13/09543-7)

DE OLIVEIRA, RENATA CABRERA; DO NASCIMENTO QUEIROZ, SONIA CLAUDIA; PINTO DA LUZ, CYNTHIA FERNANDES; PORTO, RAFAEL SILVEIRA; RATH, SUSANNE. Bee pollen as a bioindicator of environmental pesticide contamination. Chemosphere, v. 163, p. 525-534, NOV 2016. (13/09543-7, 10/18253-4)

PERES, M. S.; MANIERO, M. G.; GUIMARAES, J. R.. Photocatalytic degradation of ofloxacin and evaluation of the residual antimicrobial activity. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, v. 14, n. 3, p. 556-562, MAR 1 2015. (13/07817-2, 13/09543-7)

FERREIRA, FABRICIO DE OLIVEIRA; PORTO, RAFAEL SILVEIRA; RATH, SUSANNE. Aerobic dissipation of avermectins and moxidectin in subtropical soils and dissipation of abamectin in a field study. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v. 183, NOV 15 2019. (18/03571-2, 13/09543-7, 13/25670-9)

DE OLIVEIRA NETO, ODILON FRANCA; ARENAS, ALEJANDRO YOPASA; FOSTIER, ANNE HELENE. Sorption of thiabendazole in sub-tropical Brazilian soils. Environmental Science and Pollution Research, v. 24, n. 19, p. 10-pg., 2017-07-01. (09/17470-4, 13/09543-7)

MARTINEZ-MEJIA, MONICA J.; SATO, ISABELA; RATH, SUSANNE. Sorption mechanism of enrofloxacin on humic acids extracted from Brazilian soils. Environmental Science and Pollution Research, v. 24, n. 19, p. 12-pg., 2017-07-01. (12/01767-0, 13/09543-7)

SPINA-CRUZ, MYLENA; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Advanced oxidation processes on doxycycline degradation: monitoring of antimicrobial activity and toxicity. Environmental Science and Pollution Research, v. 26, n. 27, p. 16-pg., 2019-09-01. (13/04656-8, 13/07817-2, 13/09543-7)

LIMA VENANCIO, WILSON AUGUSTO; RODRIGUES-SILVA, CAIO; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Photocatalytic removal of fluoroquinolones and their antimicrobial activity from water matrices at trace levels: a comparison of commercial TiO2 catalysts. WATER SCIENCE AND TECHNOLOGY, v. 78, n. 8, p. 1668-1678, NOV 2018. (14/06201-0, 13/07817-2, 13/09543-7, 14/16622-3, 14/06064-3)

MARQUES, TAMIRES VALIM; RIZZATO PASCHOAL, JONAS AUGUSTO; COELHO BARONE, RAFAEL SIMOES; POSSEBON CYRINO, JOSE EURICO; RATH, SUSANNE. Depletion study and estimation of withdrawal periods for florfenicol and florfenicol amine in pacu (Piaractus mesopotamicus). AQUACULTURE RESEARCH, v. 49, n. 1, p. 111-119, JAN 2018. (13/09543-7)

RIBEIRO, CYNTIA CABRAL; ORLANDO, RICARDO MATHIAS; RODRIGUES ROHWEDDER, JARBAS JOSE; REYES REYES, FELIX GUILLERMO; RATH, SUSANNE. Electric field-assisted solid phase extraction and cleanup of ionic compounds in complex food matrices: Fluoroquinolones in eggs. Talanta, v. 152, p. 498-503, MAY 15 2016. (12/11401-3, 13/09543-7, 08/03064-1, 08/57808-1)

RODRIGUES-SILVA, CAIO; PORTO, RAFAEL S.; DOS SANTOS, SABRINA G.; SCHNEIDER, JERUSA; RATH, SUSANNE. Fluoroquinolones in Hospital Wastewater: Analytical Method, Occurrence, Treatment with Ozone and Residual Antimicrobial Activity Evaluation. Journal of the Brazilian Chemical Society, v. 30, n. 7, p. 1447-1457, JUL 2019. (13/09543-7, 18/03571-2, 14/50951-4)

DUARTE DE OLIVEIRA, AMANDA MARCHI; MANIERO, MILENA GUEDES; RODRIGUES-SILVA, CAIO; GUIMARAES, JOSE ROBERTO. Antimicrobial activity and acute toxicity of ozonated lomefloxacin solution. Environmental Science and Pollution Research, v. 24, n. 7, p. 6252-6260, MAR 2017. (13/04656-8, 13/09543-7, 13/07817-2, 14/16622-3)

PORTO, RAFAEL SILVEIRA; PINHEIRO, RAFAEL SILVIO BONILHA; RATH, SUSANNE. Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta. Environmental Science and Pollution Research, v. 28, n. 42, p. 59040-59049, NOV 2021. (18/03571-2, 13/09543-7)

ESPINDOLA, JONATHAN C.; CAIANELO, MARLON; SCACCIA, NAZARENO; RODRIGUES-SILVA, CAIO; GUIMARAES, JOSE R.; VILAR, VITOR J. P.. Trace organic contaminants removal from municipal wastewater using the FluHelik reactor: From laboratory-scale to pre-pilot scale. JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING, v. 9, n. 2, APR 2021. (13/09543-7, 18/03571-2, 14/50951-4)

TETZNER, NATALIA FERNANDA; RATH, SUSANNE. Veterinary antimicrobials and antiparasitics in fee-fishing ponds: analytical method and occurrence({*}). INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY, v. 98, n. 15, SI, p. 1354-1369, DEC 8 2018. (13/09543-7, 14/50951-4, 18/03571-2)

MARTINEZ-MEJIA, MONICA J.; SATO, ISABELA; RATH, SUSANNE. Sorption mechanism of enrofloxacin on humic acids extracted from Brazilian soils. Environmental Science and Pollution Research, v. 24, n. 19, SI, p. 15995-16006, JUL 2017. (13/09543-7, 12/01767-0)

CAIANELO, MARLON; ESPINDOLA, JONATHAN C.; DINIZ, VINICIUS; SPINA, MYLENA; RODRIGUES-SILVA, CAIO; GUIMARAES, JOSE ROBERTO. Gatifloxacin photocatalytic degradation in different water matrices: Antimicrobial activity and acute toxicity reduction. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, v. 430, p. 9-pg., 2022-09-01. (21/01416-2, 14/50951-4, 18/03571-2, 13/09543-7, 20/13094-7)

RIBEIRO URBANO, VANESSA; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO; DEL VALLE, LUIS J.; PEREZ-MOYA, MONTSERRAT. Sulfaquinoxaline Oxidation and Toxicity Reduction by Photo-Fenton Process. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 18, n. 3, FEB 2021. (13/09543-7, 13/04656-8, 13/07817-2)

RATH, SUSANNE; FOSTIER, ANNE HELENE; PEREIRA, LEANDRO ALVES; DIONISO, ANDREZA CAMILOTTI; FERREIRA, FABRICIO DE OLIVEIRA; DORETTO, KEITY MARGARETH; PERUCHI, LIVIA MANIERO; VIERA, ALESSANDRA; DE OLIVEIRA NETO, ODILON FRANCA; DAL BOSCO, SANDRA MARIA; et al. Sorption behaviors of antimicrobial and antiparasitic veterinary drugs on subtropical soils. Chemosphere, v. 214, p. 111-122, JAN 2019. (12/01767-0, 14/16995-4, 13/25670-9, 13/09543-7, 18/03571-2)

URBANO, VANESSA RIBEIRO; PERES, MARCELA SOUZA; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Abatement and toxicity reduction of antimicrobials by UV/H2O2 process. Journal of Environmental Management, v. 193, p. 439-447, MAY 15 2017. (13/04656-8, 13/09543-7, 13/07817-2)

CAIANELO, MARLON; RODRIGUES-SILVA, CAIO; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Antimicrobial activity against Gram-positive and Gram-negative bacteria during gatifloxacin degradation by hydroxyl radicals. Environmental Science and Pollution Research, v. 24, n. 7, p. 6288-6298, MAR 2017. (14/16622-3, 14/06064-3, 13/09543-7, 13/04656-8, 13/07817-2, 14/06201-0)

GRACA, CATIA A. L.; MANIERO, MILENA GUEDES; DE ANDRADE, LIDIANE MARIA; GUIMARAES, JOSE ROBERTO; TEIXEIRA, ANTONIO CARLOS S. C.. Evaluation of amicarbazone toxicity removal through degradation processes based on hydroxyl and sulfate radicals. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING, v. 54, n. 11, JULY 2019. (13/09543-7, 13/07817-2, 13/50218-2, 13/04656-8)

PORTO, RAFAEL SILVEIRA; RODRIGUES-SILVA, CAIO; SCHNEIDER, JERUSA; RATH, SUSANNE. Benzimidazoles in wastewater: Analytical method development, monitoring and degradation by photolysis and ozonation. Journal of Environmental Management, v. 232, p. 729-737, FEB 15 2019. (13/09543-7, 14/16622-3, 14/50951-4, 18/03571-2)

CAIANELO, MARLON; RODRIGUES-SILVA, CAIO; MANIERO, MILENA GUEDES; DINIZ, VINICIUS; SPINA, MYLENA; GUIMARAES, JOSE ROBERTO. Evaluation of residual antimicrobial activity and acute toxicity during the degradation of gatifloxacin by ozonation. WATER SCIENCE AND TECHNOLOGY, v. 84, n. 1, p. 225-236, JUL 1 2021. (18/03571-2, 14/50951-4, 13/09543-7, 14/16622-3)

VENANCIO, WILSON AUGUSTO LIMA; RODRIGUES-SILVA, CAIO; SPINA, MYLENA; DINIZ, VINICIUS; GUIMARAES, JOSE ROBERTO. Degradation of benzimidazoles by photoperoxidation: metabolites detection and ecotoxicity assessment using Raphidocelis subcapitata microalgae and Vibrio fischeri. Environmental Science and Pollution Research, v. 28, n. 19, SI, p. 23742-23752, MAY 2021. (13/09543-7, 14/50951-4, 18/03571-2)

SAENZ, JOHAN S.; MARQUES, TAMIRES VALIM; COELHO BARONE, RAFAEL SIMOES; POSSEBON CYRINO, JOSE EURICO; KUBLIK, SUSANNE; NESME, JOSEPH; SCHLOTER, MICHAEL; RATH, SUSANNE; VESTERGAARD, GISLE. Oral administration of antibiotics increased the potential mobility of bacterial resistance genes in the gut of the fish Piaractus mesopotamicus. MICROBIOME, v. 7, FEB 18 2019. (13/09543-7)

FERREIRA, FABRICIO DE OLIVEIRA; RODRIGUES-SILVA, CAIO; RATH, SUSANNE. On-line solid-phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry for the determination of avermectins and milbemycin in soils. Journal of Chromatography A, v. 1471, p. 118-125, NOV 4 2016. (13/09543-7, 14/16622-3, 13/25670-9)

RATH, SUSANNE; PEREIRA, LEANDRO ALVES; DAL BOSCO, SANDRA MARIA; MANIERO, MILENA GUEDES; FOSTIER, ANNE HELENE; GUIMARAES, JOSE ROBERTO. Fate of ivermectin in the terrestrial and aquatic environment: mobility, degradation, and toxicity towards Daphnia similis. Environmental Science and Pollution Research, v. 23, n. 6, p. 5654-5666, MAR 2016. (13/07817-2, 13/09543-7, 09/17470-4)

ALESSANDRA PAULA VIEIRA; SUSANNE RATH; ANNE HÉLÈNE FOSTIER. Sorption of Sulfachloropyridazine in Brazilian Soils. Journal of the Brazilian Chemical Society, v. 28, n. 1, p. 158-167, 2017-01-00. (13/09543-7, 09/17470-4)

RAFAEL S. PORTO; SUSANNE RATH; SONIA C. N. QUEIROZ. Conyza canadensis: Green Extraction Method of Bioactive Compounds and Evaluation of Their Antifungal Activity. Journal of the Brazilian Chemical Society, v. 28, n. 5, p. 913-919, 2017-05-00. (13/09543-7)

TETZNER, NATALIA FERNANDA; MANIERO, MILENA GUEDES; RODRIGUES-SILVA, CAIO; RATH, SUSANNE. On-line solid phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry as a powerful technique for the determination of sulfonamide residues in soils. Journal of Chromatography A, v. 1452, p. 89-97, JUN 24 2016. (13/07817-2, 13/09543-7, 14/16622-3, 14/06201-0)

DE OLIVEIRA, AMANDA M. D.; MANIERO, MILENA G.; GUIMARAES, JOSE R.. Lomefloxacin Degradation: Antimicrobial Activity, Toxicity and Byproducts. JOURNAL OF ADVANCED OXIDATION TECHNOLOGIES, v. 18, n. 2, p. 211-220, JUL 31 2015. (13/07817-2, 13/09543-7, 13/04656-8)

SUSANNE RATH; MÓNICA JOHANNA MARTÍNEZ-MEJIA; CLÁUDIA HOFFMANN KOWALSKI SCHRÖDER. CONSIDERAÇÕES E IMPLICAÇÕES PRÁTICAS DO GUIA DE VALIDAÇÃO E CONTROLE DE QUALIDADE ANALÍTICA DE FÁRMACOS EM PRODUTOS PARA ALIMENTAÇÃO ANIMAL E MEDICAMENTOS VETERINÁRIOS. Química Nova, v. 38, n. 5, p. 697-708, 2015-06-00. (09/10443-1, 13/09543-7)

GIRELI, GLENDA ARAUJO S.; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Influence of pH value on sulfonamide ozonation using caffeine as a contamination indicator. WATER SCIENCE AND TECHNOLOGY-WATER SUPPLY, v. 20, n. 2, p. 508-515, MAR 2020. (13/09543-7, 13/07817-2)

ESPINDOLA, JONATHAN C.; CAIANELO, MARLON; SCACCIA, NAZARENO; RODRIGUES-SILVA, CAIO; GUIMARAES, JOSE R.; VILAR, VITOR J. P.. Trace organic contaminants removal from municipal wastewater using the FluHelik reactor: From laboratory-scale to pre-pilot scale. JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING, v. 9, n. 2, p. 10-pg., 2021-01-21. (13/09543-7, 18/03571-2, 14/50951-4)

URBANO, VANESSA RIBEIRO; MANIERO, MILENA GUEDES; PEREZ-MOYA, MONTSERRAT; GUIMARAES, JOSE ROBERTO. Influence of pH and ozone dose on sulfaquinoxaline ozonation. Journal of Environmental Management, v. 195, p. 8-pg., 2017-06-15. (14/06064-3, 13/04656-8, 13/09543-7, 14/06201-0, 13/07817-2)

GRACA, CATIA A. L.; FUGITA, LUCAS T. N.; DE VELOSA, ADRIANA CORREIA; TEIXEIRA, ANTONIO CARLOS S. C.. Amicarbazone degradation promoted by ZVI-activated persulfate: study of relevant variables for practical application. Environmental Science and Pollution Research, v. 25, n. 6, p. 10-pg., 2018-02-01. (13/09543-7, 13/04656-8, 13/50218-2)

TETZNER, NATALIA FERNANDA; RATH, SUSANNE. Veterinary antimicrobials and antiparasitics in fee-fishing ponds: analytical method and occurrence(*). INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY, v. 98, n. 15, p. 16-pg., 2018-12-08. (14/50951-4, 13/09543-7, 18/03571-2)