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Evaluation of the antimicrobial activity and cytotoxicity of cationic peptide fragments isolated or in combination in the prevention of dental caries.

Grant number: 13/12285-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2013
Effective date (End): September 30, 2016
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal Investigator:Cristiane Duque
Grantee:Paula Fernanda Kreling Domingues
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil
Associated scholarship(s):14/13806-6 - Molecular study of new bacterial species and antimicrobial agents to control multispecies biofilms associated with early childhood caries, BE.EP.DR


The early childhood caries (ECC) is a microbial infection which can severely affect the dentition of young children. The etiology of the ECC involves selective bacterial infection, diet and host factors. In the oral cavity, components of the innate immune system, such as cationic antimicrobial peptides (CAPs), are responsible for maintaining the ecological balance and absence of opportunistic infections. The presence of CAPs in saliva can be a biological factor that contributes to the resistance to caries due to their broad antimicrobial and immuneregulatory activity. Studies have shown that children with ECC have lower levels of some CAPs when compared to caries-free children. The aims of this study are evaluated: 1) in vitro antimicrobial action of isolated/combined CAPs fragments on potentially cariogenic dental microorganisms and 2) toxicity these fragments on epithelial cell. In summary, standard bacterial strains and clinical isolates of S. mutans will be used to evaluate the antimicrobial activity of synthetic CAPs fragments isolated or combined by tests of MIC/MBC and biofilm. The fragments that achieve the best potential antimicrobial will be evaluated for their toxicity on epithelial cells. The data will be analyzed statistically. This study intends to evaluate the antimicrobial activity of CAPs fragments in the prevention of dental caries.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FIORAMONTI CALIXTO, GIOVANA MARIA; DUQUE, CRISTIANE; AIDA, KELLY LIMI; DOS SANTOS, VANESSA RODRIGUES; MASSUNARI, LOIANE; CHORILLI, MARLUS. Development and characterization of p1025-loaded bioadhesive liquid-crystalline system for the prevention of Streptococcus mutans biofilms. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 13, p. 31-41, . (13/01565-1, 13/12285-0, 12/19235-5)
AIDA, KELLY LIMI; KRELING, PAULA FERNANDA; CAIAFFA, KARINA SAMPAIO; FIORAMONTI CALIXTO, GIOVANA MARIA; CHORILLI, MARLUS; SPOLIDORIO, DENISE M. P.; SANTOS-FILHO, NORIVAL ALVES; CILLI, EDUARDO MAFFUD; DUQUE, CRISTIANE. Antimicrobial peptide-loaded liquid crystalline precursor bioadhesive system for the prevention of dental caries. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 13, p. 3081-3091, . (13/01565-1, 13/12285-0, 13/07600-3, 12/19235-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
DOMINGUES, Paula Fernanda Kreling. Cytotoxicity and microbiological effect of cationic peptide fragments isolated or combined for dental caries prevention. 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araçatuba Araçatuba.

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