The prognostic value of histopathological grading systems in oral squamous cell carcinomas

Autor(es):Mostrar menos -

Sawazaki-Calone, I. ^{[1, 2]} ; Rangel, A. L. C. A. ^[1] ; Bueno, A. G. ^[3] ; Morais, C. F. ^[4] ; Nagai, H. M. ^[5] ; Kunz, R. P. ^[6] ; Souza, R. L. ^[1] ; Rutkauskis, L. ^[1] ; Salo, T. ^{[7, 8, 9, 2]} ; Almangush, A. ^{[7, 8, 9]} ; Coletta, R. D. ^[2]

Afiliação do(s) autor(es)

^[1] Western Parana State Univ, Sch Dent, Oral Pathol & Oral Med, BR-85819110 Cascavel, PR - Brazil

^[2] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba - Brazil

^[3] ANATOM Anat Pathol Lab, Cascavel - Brazil

^[4] APC Anat Pathol Lab, Cascavel - Brazil

^[5] UOPECCAN Canc Hosp, Cascavel - Brazil

^[6] Oncol Ctr Cascavel CEONC, Cascavel - Brazil

^[7] Univ Oulu, Oulu Univ Hosp, Oulu - Finland

^[8] Univ Helsinki, Inst Dent, Helsinki - Finland

^[9] Univ Oulu, Inst Dent, Dept Diagnost & Oral Med, Oulu - Finland

• Tipo de documento: Artigo Científico
• Fonte: ORAL DISEASES; v. 21, n. 6, p. 755-761, SEP 2015.
• Citações Web of Science: 22

Resumo

ObjectiveThis study evaluated the association of four histopathological grading systems (WHO grading system, malignancy grading of the deep invasive margins (MG), histological risk (HR) model, and tumor budding and depth of invasion (BD) model) with clinicopathological parameters and outcome of 113 oral squamous cell carcinomas to identify their roles in prognosis. MethodsDemographic and clinical features were obtained from patients' records. Sections from all paraffin-embedded blocks were evaluated according to the four grading systems. Demographic and clinical associations were analyzed using chi-square test, and correlations between the grading systems were established with the Spearman's rank correlation test. Survival curves were performed with Kaplan-Meier method, and multivariate analysis based on Cox proportional hazard model was calculated. ResultsSignificant associations with survival were observed for WHO grading system and BD model in the univariate analysis, but only the BD model was significantly associated with disease outcome as an independent prognostic marker. Age, tumor size, and presence of regional metastasis were also independent markers of reduced survival. ConclusionA significant association between the BD model and outcome of OSCC patients was observed, indicating this new histopathological grading system as a possible prognostic tool. (AU)

• Processo FAPESP: 13/01607-6 - Avaliação do papel biológico das proteínas EEF1D, fascina e plectina em carcinomas espinocelulares orais
• Beneficiário: Ricardo Della Coletta
• Modalidade de apoio: Auxílio à Pesquisa - Regular