Polymeric and Solid Lipid Nanoparticles for Sustained Release of Carbendazim and Tebuconazole in Agricultural Applications

Autor(es)

Ramos Campos, Estefania Vangelie ^{[1, 2]} ; de Oliveira, Jhones Luiz ^[1] ; Goncalves da Silva, Camila Morais ; Pascoli, Monica ^[3] ; Pasquoto, Tatiane ^[3] ; Lima, Renata ^[3] ; Abhilash, P. C. ^[4] ; Fraceto, Leonardo Fernandes ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] State Univ Sao Paulo UNESP, Dept Environm Engn, Sorocaba, SP - Brazil

^[2] State Univ Campinas UNICAMP, Inst Biol, Dept Biochem, Campinas, SP - Brazil

^[3] Univ Sorocaba, Dept Biotechnol, Sorocaba, SP - Brazil

^[4] Banaras Hindu Univ, Inst Environm & Sustainable Dev, Varanasi 221005, Uttar Pradesh - India

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 5, SEP 8 2015.
• Citações Web of Science: 34

Resumo

Carbendazim (MBC) (methyl-2-benzimidazole carbamate) and tebuconazole (TBZ) ((RS)-1(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl) pentan-3-ol) are widely used in agriculture for the prevention and control of fungal diseases. Solid lipid nanoparticles and polymeric nanocapsules are carrier systems that offer advantages including changes in the release profiles of bioactive compounds and their transfer to the site of action, reduced losses due to leaching or degradation, and decreased toxicity in the environment and humans. The objective of this study was to prepare these two types of nanoparticle as carrier systems for a combination of TBZ and MBC, and then investigate the release profiles of the fungicides as well as the stabilities and cytotoxicities of the formulations. Both nanoparticle systems presented high association efficiency (> 99%), indicating good interaction between the fungicides and the nanoparticles. The release profiles of MBC and TBZ were modified when the compounds were loaded in the nanoparticles, and cytotoxicity assays showed that encapsulation of the fungicides decreased their toxicity. These fungicide systems offer new options for the treatment and prevention of fungal diseases in plants. (AU)

• Processo FAPESP: 13/12322-2 - Nanopartículas como sistema carreadores de compostos bioativos visando aplicações em agricultura
• Beneficiário: Leonardo Fernandes Fraceto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/16989-9 - Desenvolvimento de nanopartículas como sistema carreador para os fungicidas Carbendazim e Tebuconazol visando aplicações em agricultura
• Beneficiário: Estefânia Vangelie Ramos Campos
• Modalidade de apoio: Bolsas no Brasil - Mestrado