Molecular Dynamics Simulations of the Initial-State Predict Product Distributions of Dediazoniation of Aryldiazonium in Binary Solvents

Autor(es)

Cruz, Gustavo N. ^[1] ; Lima, Filipe S. ^[1] ; Dias, Luis G. ^[2] ; El Seoud, Omar A. ^[3] ; Horinek, Dominik ^[4] ; Chaimovich, Hernan ^[1] ; Cuccovia, Iolanda M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Bioquim, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Inst Quim, Sao Paulo - Brazil

^[4] Univ Regensburg, Inst Phys & Theoret Chem, D-93053 Regensburg - Germany

• Tipo de documento: Artigo Científico
• Fonte: Journal of Organic Chemistry; v. 80, n. 17, p. 8637-8642, SEP 4 2015.
• Citações Web of Science: 2

Resumo

The dediazoniation of aryldiazonium salts in mixed solvents proceeds by a borderline S(N)1 and S(N)2 pathway, and product distribution should be proportional to the composition of the solvation shell of the carbon attached to the -N-2 group (ipso carbon). The rates of dediazoniation of 2,4,6-trimethylbenzenediazonium in water, methanol, ethanol, propanol, and acetonitrile were similar, but measured product distributions were noticeably dependent on the nature of the water/cosolvent mixture. Here we demonstrated that solvent distribution in the first solvation shell of the ipso carbon, calculated from classical molecular dynamics simulations, is equal to the measured product distribution. Furthermore, we showed that regardless of the charge distribution of the initial state, i.e., whether the positive charge is smeared over the molecule or localized on phenyl moiety, the solvent distribution around the reaction center is nearly the same. (AU)

• Processo FAPESP: 14/06073-2 - Determinando a origem de transições de forma em sistemas micelares no nível atômico: um estudo computacional
• Beneficiário: Filipe da Silva Lima
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 13/08166-5 - Química em interfaces: interações de fármacos, peptídios e enzimas com membranas modelos
• Beneficiário: Iolanda Midea Cuccovia
• Modalidade de apoio: Auxílio à Pesquisa - Temático