Electrochemical investigation of the voltammetric determination of hydrochlorothiazide using a nickel hydroxide modified nickel electrode

Autor(es)

Machini, Wesley B. S. ^[1] ; David-Parra, Diego N. ^[1] ; Teixeira, Marcos F. S. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Fac Sci & Technol, BR-19060900 Presidente Prudente, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 57, p. 344-348, DEC 1 2015.
• Citações Web of Science: 9

Resumo

The preparation and electrochemical characterization of a nickel hydroxide modified nickel electrode as well as its behavior as electrocatalyst toward the oxidation of hydrochlorothiazide (HCTZ) were investigated. The electrochemical behavior of the modified electrode and the electrooxidation of HCTZ were explored using cyclic voltammetry. The voltammetric response of the modified electrode in the detection of HCTZ is based on the electrochemical oxidation of the Ni(II)/Ni(III) and a chemical redox process. The analytical parameters for the electrooxidation of HCTZ by the nickel hydroxide modified nickel electrode were obtained in NaOH solution, in which the linear voltammetric response was in the concentration range from 1.39 x 10(-5) to 1.67 x 10(-4) Mol L-1 with a limit of detection of 7.92 x 10(-6) Mol L-1 and a sensitivity of 0.138 mu A L mmol(-1). Tafel analysis was used to elucidate the kinetics and mechanism of HCTZ oxidation by the modified electrode. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 05/01296-4 - Desenvolvimento de metodologia analítica empregando eletrodos modificados com oxo complexos polinucleares de rutênio encapsulado em zeolita
• Beneficiário: Marcos Fernando de Souza Teixeira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 13/10469-6 - Aplicação eletroanalítica de complexo biomimetizador de manganês(IV) contendo ligante 2,3,5,6-tetraquis(2-piridil)pirazina
• Beneficiário: Wesley Bruno da Silva Machini
• Modalidade de apoio: Bolsas no Brasil - Mestrado