Periodontitis Response to Anti-TNF Therapy in Ankylosing Spondylitis

Autor(es)

Fabri, Gisele Maria C. ^[1] ; Pereira, Rosa Maria R. ^[2] ; Savioli, Cynthia ^[3] ; Saad, Carla G. S. ^[2] ; de Moraes, Julio Cesar B. ^[2] ; Siqueira, Jose Tadeu T. ^[3] ; Bonfa, Eloisa ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Juiz de Fora, Sch Dent, Juiz De Fora, MG - Brazil

^[2] Univ Sao Paulo, Hosp Clin, Div Rheumatol, BR-05403010 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Hosp Clin, Dent Div, BR-05403010 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JCR-JOURNAL OF CLINICAL RHEUMATOLOGY; v. 21, n. 7, p. 341-345, OCT 2015.
• Citações Web of Science: 7

Resumo

Background Recently, it has been demonstrated that patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) have a higher risk of periodontitis; however, the effect of anti-TNF therapy in periodontal status of patients with AS and particularly in dental attachment is not known. Objective To evaluate longitudinally the local periodontal effect of TNF-antagonist in AS and compare to patients with RA. Methods Fifteen patients with AS and 15 RA control patients were prospectively evaluated at baseline and after 6 months (6 M) of anti-TNF therapy. Periodontal assessment included: probing pocket depth (PPD), clinical attachment level (CAL), gingival bleeding index, and plaque index. Rheumatologic clinical and laboratory evaluations were the following: Bath AS Disease Activity Index, Bath AS Metrology Index, Bath AS Functional Index, C-reactive protein and erythrocyte sedimentation rate for AS and Disease Activity Score 28 joints, and C-reactive protein and erythrocyte sedimentation rate for patients with RA. Results At baseline, periodontal parameters were alike in AS and RA (P > 0.05). After 6 M of anti-TNF therapy, clinical and laboratory parameters of rheumatic diseases decreased significantly in the patients with AS and RA (P < 0.05). A significant improvement in periodontal attachment measurements were observed in the patients with AS (PPD, 2.18 vs 1.94 mm; P = 0.02; CAL, 2.29 vs.2.02 mm; P = 0.03), but not in RA (PPD, 1.92 vs 2.06 mm; P = 0.06; CAL, 2.14 vs 2.28 mm; P = 0.27). Oral hygiene and gingival inflammation remained unchanged from baseline to 6-M evaluation in AS and RA (P > 0.05). Conclusion Patients with AS under anti-TNF improved periodontal attachment. The mechanism for this effect needs further studies. (AU)

• Processo FAPESP: 10/12035-5 - Terapia anti-TNF em doenças auto-imunes reumatológicas: abordagem de aspectos peculiares
• Beneficiário: Gisele Maria Campos Fabri
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 09/51897-5 - Terapia anti-TNF em doenças auto-imunes reumatológicas: abordagem de aspectos peculiares
• Beneficiário: Eloisa Silva Dutra de Oliveira Bonfá
• Modalidade de apoio: Auxílio à Pesquisa - Temático