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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Treatment of periodontal disease with an Er,Cr:YSGG laser in rats exposed to cigarette smoke inhalation

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Autor(es):
Pavone, Chaine [1] ; Boas Nogueira, Andressa Vilas [1] ; Pimentel Lopes de Oliveira, Guilherme Jose [1] ; Scardueli, Cassio Rocha [1] ; Cerri, Paulo Sergio [1] ; Marcantonio, Jr., Elcio [1] ; Chierici Marcantonio, Rosemary Adriana [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Sao Paulo Univ Julio de Mesquita Filho, Araraquara Dent Sch, Araraquara, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Lasers in Medical Science; v. 30, n. 8, p. 2095-2103, NOV 2015.
Citações Web of Science: 3
Resumo

The purpose of this study was to evaluate the erbium, chromium:yttrium-scandiumgallium-garnet (Er,Cr:YSGG) laser irradiation in the treatment of periodontitis in rats exposed to cigarette smoke inhalation (CSI). Ligatures were placed in the maxillary second molars. After a 15-day period, the ligatures were removed and 180 animals were randomly divided into six groups: (1) CSRP group-CSI and manual scaling and root planing (SRP) treatment; (2) CL group-CSI and Er,Cr:YSGG laser irradiation; (3) CSRP + L group-CSI, SRP, and Er,Cr:YSGG irradiation; (4) SRP group-manual SRP; (5) L group-Er,Cr:YSGG irradiation; (6) SRP + L group-SRP and Er,Cr:YSGG irradiation. At 7, 15, and 30 days after treatments, animals were euthanized and histologic, histometric, immunohistochemistry, and real-time PCR analyses were performed. Histometrically, no differences were observed in the SRP, L, and SRP + L groups exposed to CSI. The CSRP group showed more bone formation at 30 days than at 15 days (p < 0.01) but less bone at 30 days than the CL group at 30 days (p < 0.05). Immunohistochemical staining was positive for osteoblasts, fibroblasts, and osteoclasts. Real-time PCR showed more (vascular endothelial growth factor) VEGF expression in the L (p < 0.05) and SRP + L (p < 0.01) groups at 30 days than at 15 days and less VEGF expression in the CSRP group at 30 days than at 15 days (p < 0.05). There was no difference in fibroblast growth factor (FGF) expression. The Er,Cr:YSGG laser irradiation promotes favorable conditions for tissue repair even in animals exposed to CSI, with similar results as those achieved from manual scaling and root planing. (AU)

Processo FAPESP: 10/16661-8 - Avaliação dos efeitos do laser Er,Cr:YSGG em defeitos ósseos críticos e no tratamento de doença periodontal induzida em ratos submetidos a inalação de fumaça de cigarro
Beneficiário:Rosemary Adriana Chierici Marcantonio
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/17639-9 - Avaliação dos efeitos do Laser ER,CR:YSGG em defeitos ósseos críticos e no tratamento de doença periodontal induzida em ratos submetidos a inalação de fumaça de cigarro.
Beneficiário:Chaine Pavone
Modalidade de apoio: Bolsas no Brasil - Doutorado