| Texto completo | |
| Autor(es): |
Souza, Frederico B.
[1]
;
Shamim, Anwar
[2]
;
Argomedo, Luiz M. Z.
[1]
;
Pimenta, Daniel C.
[3]
;
Stefani, Helio A.
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Quim, Sao Paulo, SP - Brazil
[3] Inst Butantan, Sao Paulo, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MOLECULAR DIVERSITY; v. 19, n. 4, p. 773-785, NOV 2015. |
| Citações Web of Science: | 3 |
| Resumo | |
An efficient methodology for the synthesis of aryl-substituted vinyl sulfoxides through direct substitution of aryl-substituted alkynyl grignard reagents on menthyl-p-toluenesulfinate followed by Suzuki-Miyaura cross-coupling reaction has been developed. It has also been described that the reaction of alkyl-substituted and cycloalkyl-substituted alkynyl grignard reagents with menthyl-p-toluenesulfinate led to two products, i.e., alkynyl sulfoxide derivatives, as a result of substitution, and enyne sulfoxide derivatives, which resulted from substitution followed by Michael type addition. It was possible to selectively synthesize the enyne sulfoxide derivatives by changing the concentration of the grignard reagent. These alkenyl sulfoxides were transformed into the corresponding -thio aldehydes in high yields via additive Pummerer rearrangement. (AU) | |
| Processo FAPESP: | 13/20553-4 - Síntese e funcionalização de iodeto de sulfóxidos vinílicos |
| Beneficiário: | Frederico Bernardes de Souza |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 12/00424-2 - Síntese de pequenas bibliotecas empregando organotrifluoroboratos de potássio em reações de Suzuki-Miyaura |
| Beneficiário: | Helio Alexandre Stefani |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 11/11499-0 - Aplicação de bioisosterismo no planejamento de agentes antichagásicos: integração entre estratégias computacionais e experimentais |
| Beneficiário: | Gustavo Henrique Goulart Trossini |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |