Formation of carrageenan-CaCO3 bioactive membranes

Autor(es)

Nogueira, Lucas F. B. ^[1] ; Maniglia, Bianca C. ^[1] ; Pereira, Lourivaldo S. ^[1] ; Tapia-Blacido, Delia R. ^[1] ; Ramos, Ana P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-05508 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 58, p. 1-6, JAN 1 2016.
• Citações Web of Science: 8

Resumo

The high biocompatibility and resorbability of polymeric membranes have encouraged their use to manufacture medical devices. Here, we report on the preparation of membranes consisting of carrageenan, a naturally occurring sulfated polysaccharide that forms helical structures in the presence of calcium ions. We incorporated CaCO3 particles into the membranes to enhance their bioactivity and mechanical properties. Infrared spectroscopy and X-ray diffraction data confirmed CaCO3 incorporation into the polymeric matrix. We tested the bioactivity of the samples by immersing them in a solution that mimics the ionic composition and pH of the human body fluid. The hybrid membranes generated hydroxyapatite, as attested by X-ray diffraction data. Scanning electron and atomic force microscopies aided investigation of membrane topography before and after CaCO3 deposition. The wettability and surface free energy, evaluated by contact angle measures, increased in the presence of CaCO3 particles. These parameters are important for membrane implantation in the body. Moreover, membrane stiffness was up to 110% higher in the presence of the inorganic particles, as revealed by Young's modulus. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/20946-3 - Estudo do crescimento de fosfatos e carbonatos de cálcio sobre matrizes orgânicas depositadas sobre suportes metálicos: obtenção de biomateriais osteoindutores
• Beneficiário: Ana Paula Ramos
• Modalidade de apoio: Auxílio à Pesquisa - Regular