Square-Wave Voltammetric Determination of Paracetamol and Codeine in Pharmaceutical and Human Body Fluid Samples Using a Cathodically Pretreated Boron-Doped Diamond Electrode

Autor(es)

Santos, Anderson M. ^[1] ; Vicentini, Fernando C. ^[1] ; Deroco, Patricia B. ^[1] ; Rocha-Filho, Romeu C. ^[1] ; Fatibello-Filho, Orlando ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 26, n. 10, p. 2159-2168, OCT 2015.
• Citações Web of Science: 22

Resumo

Simple, fast, and inexpensive electroanalytical procedures were developed for the determination of codeine (COD) solely and paracetamol (PCT) and COD simultaneously in pharmaceutical formulations and human body fluids. The methods involve the combination of square-wave voltammetry (SWV) with a cathodically pretreated boron-doped diamond electrode and a 0.2 mol L–1 acetate buffer (pH 4.0) solution as the supporting electrolyte. Significantly low limits of detection were obtained for COD solely or PCT and COD simultaneously: 1.19 or 18 and 14 nmol L–1, respectively. The proposed SWV method was successfully applied in the simultaneous determination of PCT and COD in four samples of pharmaceutical tablets, with results similar (at 98% confidence level) to those obtained using a reference high-performance liquid chromatography (HPLC) method. Additionally, adequate results were obtained when concentrations of PCT and COD were determined in human urine or serum samples by addition-recovery. Clearly, the proposed method is an excellent option for the determination of COD solely or PCT and COD simultaneously. (AU)

• Processo FAPESP: 14/07919-2 - Preparação de eletrodos com novos materiais à base de carbono para aplicações em eletroanalítica
• Beneficiário: Patrícia Batista Deroco
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/16770-0 - Desenvolvimento de sensores à base de filmes poliméricos e nanomateriais para aplicações analíticas diversas
• Beneficiário: Fernando Campanhã Vicentini
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado