Optical coherence tomography imaging of the basal ganglia: feasibility and brief review

Autor(es)

Contreras Lopez, W. O. ^[1] ; Angelos, J. S. ^[1] ; Martinez, R. C. R. ^[2] ; Takimura, C. K. ^[3] ; Teixeira, M. J. ^[1] ; Lemos Neto, P. A. ^[3] ; Fonoff, E. T. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Dept Neurol, Div Neurocirurgia Func, Sao Paulo, SP - Brazil

^[2] Hosp Siriolibanes, Lab Neuromodulacao & Dor Expt, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Inst Coracao, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 48, n. 12, p. 1156-1159, DEC 2015.
• Citações Web of Science: 3

Resumo

Optical coherence tomography (OCT) is a promising medical imaging technique that uses light to capture real-time cross-sectional images from biological tissues in micrometer resolution. Commercially available optical coherence tomography systems are employed in diverse applications, including art conservation and diagnostic medicine, notably in cardiology and ophthalmology. Application of this technology in the brain may enable distinction between white matter and gray matter, and obtainment of detailed images from within the encephalon. We present, herein, the in vivo implementation of OCT imaging in the rat brain striatum. For this, two male 60-day-old rats (Rattus norvegicus, Albinus variation, Wistar) were stereotactically implanted with guide cannulas into the striatum to guide a 2.7-French diameter high-definition OCT imaging catheter (Dragonfly™, St. Jude Medical, USA). Obtained images were compared with corresponding histologically stained sections to collect imaging samples. A brief analysis of OCT technology and its current applications is also reported, as well as intra-cerebral OCT feasibility on brain mapping during neurosurgical procedures. (AU)

• Processo FAPESP: 11/08575-7 - Papel da modulação dopaminérgica no núcleo lateral da amígdala sobre a resposta condicionada de esquiva
• Beneficiário: Raquel Chacon Ruiz Martinez
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores