A high loaded cationic nanoemulsion for quercetin delivery obtained by sub-PIT method

Autor(es)

Dario, Michelli F. ^[1] ; Santos, M. Soledade C. S. ^[2] ; Viana, Ana S. ^[2] ; Areas, Elizabeth P. G. ^[3] ; Bou-Chacra, Nadia A. ^[1] ; Conceicao Oliveira, M. ^[4] ; Minas da Piedade, Manuel E. ^[2] ; Baby, Andre R. ^[1] ; Velasco, Maria Valeria R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, BR-05508000 Sao Paulo - Brazil

^[2] Univ Lisbon, Fac Ciencias, Ctr Quim & Bioquim, P-1749016 Lisbon - Portugal

^[3] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo - Brazil

^[4] Univ Lisbon, Inst Super Tecn, Ctr Quim Estrutural, P-1049001 Lisbon - Portugal

• Tipo de documento: Artigo Científico
• Fonte: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS; v. 489, p. 256-264, JAN 20 2016.
• Citações Web of Science: 9

Resumo

The incorporation of low solubility natural substances into cosmetic formulations is an industrial trend posing new challenges and opportunities for fundamental research and cost effective product development. The sub-PIT method, an easily scaled-up low energy process, was used to yield a stable reduced droplet diameter (similar to 20 nm) cationic nanoemulsion, containing a natural quercetin extract (95.5% w/w), appropriate for cosmetic application. The formulation presented optical transparency and high quercetin concentration (0.5% w/w). The preparation method was optimized in terms of mixture HLB and temperature. The best polydispersity index was achieved at 80 degrees C. Droplet diameter (DLS), zeta potential, rheological properties and nanodroplet morphology (cryo-TEM and AFM) were evaluated. This nanoemulsion contains spheric droplets with the lowest diameter ever described (to the best of our knowledge) for a cationic nanoemulsion prepared by the sub-PIT method. AFM experiments showed that the nanodroplets adsorb on a highly oriented pyrolytic graphite surface, holding a wettability similar to hair external surface. Accelerated stability assays carried out over 90 days indicated that Ostwald ripening destabilization occurred at 45 C temperature, but was not observed at room temperature. This nanoemulsion exhibits excelent characteristics for application in cosmetics and sets-up a nanotechnological platform for other cosmetic/pharmaceutical applications. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 13/16070-8 - Condicionador nanotecnológico bioativo na proteção capilar à radiação ultravioleta
• Beneficiário: Maria Valeria Robles Velasco
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/16265-3 - Desenvolvimento e avaliação da eficácia de nanoemulsão catiônica bioativa na proteção capilar aos danos foto-oxidativos
• Beneficiário: Michelli Ferrera Dario
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto