Novel binuclear mu-oxo diruthenium complexes combined with ibuprofen and ketoprofen: Interaction with relevant target biomolecules and anti-allergic potential

Autor(es)

Seuanes, Gabriela Campos ^[1] ; Moreira, Mariete Barbosa ^[1] ; Petta, Tania ^[1] ; Freire de Moraes Del Lama, Maria Perpetua ^{[2, 3]} ; Beraldo de Moraes, Luiz Alberto ^[1] ; Moraes de Oliveira, Anderson Rodrigo ^[1] ; Zumstein Georgetto Naal, Rose Mary ^{[2, 3]} ; Nikolaou, Sofia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto - Brazil

^[2] Inst Nacl Ciencia & Tecnol Bioanalit, BR-13083970 Campinas, SP - Brazil

^[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Fis & Quim, BR-14040903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Inorganic Biochemistry; v. 153, p. 178-185, DEC 2015.
• Citações Web of Science: 4

Resumo

This work presents the synthesis and characterization of two novel binuclear ruthenium compounds of general formula {[}Ru2O(carb)(2)(PY)(6)](PF6)(2), where py = pyridine and carb are the non-steroidal anti-inflammatory drugs ibuprofen (1) and ketoprofen (2). Both complexes were characterized by ESI-MS/MS spectrometry. The fragmentation patterns, which confirm the proposed structures, are presented. Besides that compounds 1 and 2 present the charge transfer transitions within 325-330 nm; and the intra-core transitions around 585 nm, which is the typical spectra profile for {[}Ru2O] analogues. This suggests the carboxylate bridge has little influence in their electronic structure. The effects of the diruthenium complexes on Ig-E mediated mast cell activation were evaluated by measuring the enzyme beta-hexosaminidase released by mast cells stimulated by antigen. The inhibitory potential of the ketoprofen complex against mast cell stimulation suggests its promising application as a therapeutic agent for treating or preventing IgE-mediated allergic diseases. In addition, in vitro metabolism assays had shown that the ibuprofen complex is metabolized by the cytochrome P450 enzymes. (C) 2015 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 12/23245-6 - Espécies liberadoras de óxido nítrico baseadas em carboxilatos de rutênio e suas interações com algumas biomoléculas de interesse
• Beneficiário: Sofia Nikolaou
• Modalidade de apoio: Auxílio à Pesquisa - Regular