| Full text | |
| Author(s): |
Seuanes, Gabriela Campos
[1]
;
Moreira, Mariete Barbosa
[1]
;
Petta, Tania
[1]
;
Freire de Moraes Del Lama, Maria Perpetua
[2, 3]
;
Beraldo de Moraes, Luiz Alberto
[1]
;
Moraes de Oliveira, Anderson Rodrigo
[1]
;
Zumstein Georgetto Naal, Rose Mary
[2, 3]
;
Nikolaou, Sofia
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto - Brazil
[2] Inst Nacl Ciencia & Tecnol Bioanalit, BR-13083970 Campinas, SP - Brazil
[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Fis & Quim, BR-14040903 Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Journal of Inorganic Biochemistry; v. 153, p. 178-185, DEC 2015. |
| Web of Science Citations: | 4 |
| Abstract | |
This work presents the synthesis and characterization of two novel binuclear ruthenium compounds of general formula {[}Ru2O(carb)(2)(PY)(6)](PF6)(2), where py = pyridine and carb are the non-steroidal anti-inflammatory drugs ibuprofen (1) and ketoprofen (2). Both complexes were characterized by ESI-MS/MS spectrometry. The fragmentation patterns, which confirm the proposed structures, are presented. Besides that compounds 1 and 2 present the charge transfer transitions within 325-330 nm; and the intra-core transitions around 585 nm, which is the typical spectra profile for {[}Ru2O] analogues. This suggests the carboxylate bridge has little influence in their electronic structure. The effects of the diruthenium complexes on Ig-E mediated mast cell activation were evaluated by measuring the enzyme beta-hexosaminidase released by mast cells stimulated by antigen. The inhibitory potential of the ketoprofen complex against mast cell stimulation suggests its promising application as a therapeutic agent for treating or preventing IgE-mediated allergic diseases. In addition, in vitro metabolism assays had shown that the ibuprofen complex is metabolized by the cytochrome P450 enzymes. (C) 2015 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 12/23245-6 - Nitric oxide releasers based on ruthenium carboxylates and their interaction with some relevant biomolecules |
| Grantee: | Sofia Nikolaou |
| Support Opportunities: | Regular Research Grants |