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Nitric oxide releasers based on ruthenium carboxylates and their interaction with some relevant biomolecules


This project proposes the synthesis and characterization of trinuclear ruthenium compounds (clusters) of general formula [Ru3O(CH3COO)6(L)2(NO)]PF6 (L = solvent molecules or pyridinic ligands) aiming to develop nitric oxide releasing species, in a controlled fashion, by means of light irradiation or by reductive reactions, in order to amplify the initial knowledgement reported in literature, which is limited to two papers focusing these compounds for biological applications. In this context, analogues with VO instead of NO may be studied in order to compare to the photoinduced liberation of NO and also the carbonyl compounds may present interesting properties from the biological view - point.This proposal will cover an important gap in the actual literature, which is the synthesis of a new and larger series of ruthenium nitrosyls based on the trinuclear clusters in such a way that, in the next two years, the group will have the opportunity to study, understand and report the behavior of the compound as a novel class of NO releasers. Besides that, we intend to expand the focus of the research performed in our group, by means of the investigation of the complexes reactivity towards biomolecules such as aminoacids, endogenous reductants, human serum albumin and ct-DNA. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CACITA, NATACHA; NIKOLAOU, SOFIA. Studying the interaction between trinuclear ruthenium complexes and human serum albumin by means of fluorescence quenching. Journal of Luminescence, v. 169, n. A, p. 115-120, JAN 2016. Web of Science Citations: 22.
CLARO REIS, FELIPE COSTA; VIANA COELHO, JOANA STEFANI; PAZIN, WALLANCE MOREIRA; NIKOLAOU, SOFIA. A new homoleptic coordination compound of ruthenium and norfloxacin and its interaction with human serum albumin. Inorganic Chemistry Communications, v. 63, p. 96-100, JAN 2016. Web of Science Citations: 4.
SEUANES, GABRIELA CAMPOS; MOREIRA, MARIETE BARBOSA; PETTA, TANIA; FREIRE DE MORAES DEL LAMA, MARIA PERPETUA; BERALDO DE MORAES, LUIZ ALBERTO; MORAES DE OLIVEIRA, ANDERSON RODRIGO; ZUMSTEIN GEORGETTO NAAL, ROSE MARY; NIKOLAOU, SOFIA. Novel binuclear mu-oxo diruthenium complexes combined with ibuprofen and ketoprofen: Interaction with relevant target biomolecules and anti-allergic potential. Journal of Inorganic Biochemistry, v. 153, p. 178-185, DEC 2015. Web of Science Citations: 4.

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Filed patent(s) as a result of this research project

COMPOSTO, PROCESSO DE OBTENÇÃO DE COMPOSTO E USOS DO MESMO BR1020150190131 - Universidade de São Paulo (USP) . Sofia Nikolaou; Rose Mary Zumstein Georgetto Naal; Mariete Barbosa Moreira; Maria Perpétua Freire De Morais Del Lama - August 2015, 07