Prevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication

Autor(es)

Schlottfeldt, Fabio dos Santos ^[1] ; Fernandes, Sheila Marques ^[1] ; Martins, Daniel Malisani ^[1] ; Cordeiro, Priscilla ^[1] ; da Fonseca, Cassiane Dezoti ^[1] ; Watanabe, Mirian ^[1] ; Fernandes Vattimo, Maria de Fatima ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Escola Enfermagem, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Escola Enfermagem, Dept Enfermagem Med Cirurg, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Revista da Escola de Enfermagem da USP; v. 49, n. SI, p. 73-78, FEB 2015.
• Citações Web of Science: 2

Resumo

Objective: To evaluate the effect of diosmin and hesperidin flavonoids in the prevention of amphotericin B nephrotoxicity, through an experimental model on rats. Method: Adult, male Wistar rats were distributed into the following groups: saline; diosmin hesperidin (animals that received 50 mg/kg of diosmin hesperidin, drinking water, for ten days); amphotericin B (animals that received 15 mg/kg/day of amphotericin B through intraperitoneal treatment for five days); amphotericin B+diosmin hesperidin. Renal function, fractional excretion of sodium; potassium and magnesium and oxidative metabolites were evaluated. Results: Treatment with amphotericin B reduced renal function, as shown by the clearance of creatinine, increased tubular function markers and fractional excretion of sodium, potassium, magnesium and oxidative metabolites. Pre-treatment with diosmin hesperidin ameliorated clearance of creatinine and reduced tubular and oxidative injury. Conclusion: Administration of amphotericin B resulted in reduction of renal function with tubular injury, and diosmin hesperidin showing an antioxidant protective effect on the kidneys. (AU)

• Processo FAPESP: 13/26560-2 - O contraste radiológico em situações de risco para nefropatia
• Beneficiário: Maria de Fatima Fernandes Vattimo
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/24028-6 - O efeito do inibidor da fosfodiestarese-5 na lesão renal aguda isquêmica em ratos
• Beneficiário: Mirian Watanabe
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado