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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication

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Author(s):
Schlottfeldt, Fabio dos Santos [1] ; Fernandes, Sheila Marques [1] ; Martins, Daniel Malisani [1] ; Cordeiro, Priscilla [1] ; da Fonseca, Cassiane Dezoti [1] ; Watanabe, Mirian [1] ; Fernandes Vattimo, Maria de Fatima [2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Escola Enfermagem, Sao Paulo - Brazil
[2] Univ Sao Paulo, Escola Enfermagem, Dept Enfermagem Med Cirurg, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Revista da Escola de Enfermagem da USP; v. 49, n. SI, p. 73-78, FEB 2015.
Web of Science Citations: 2
Abstract

Objective: To evaluate the effect of diosmin and hesperidin flavonoids in the prevention of amphotericin B nephrotoxicity, through an experimental model on rats. Method: Adult, male Wistar rats were distributed into the following groups: saline; diosmin hesperidin (animals that received 50 mg/kg of diosmin hesperidin, drinking water, for ten days); amphotericin B (animals that received 15 mg/kg/day of amphotericin B through intraperitoneal treatment for five days); amphotericin B+diosmin hesperidin. Renal function, fractional excretion of sodium; potassium and magnesium and oxidative metabolites were evaluated. Results: Treatment with amphotericin B reduced renal function, as shown by the clearance of creatinine, increased tubular function markers and fractional excretion of sodium, potassium, magnesium and oxidative metabolites. Pre-treatment with diosmin hesperidin ameliorated clearance of creatinine and reduced tubular and oxidative injury. Conclusion: Administration of amphotericin B resulted in reduction of renal function with tubular injury, and diosmin hesperidin showing an antioxidant protective effect on the kidneys. (AU)

FAPESP's process: 13/26560-2 - Iodinated contrast induced acute kidney injury in diabetic and nephropathy diabetic in rats
Grantee:Maria de Fatima Fernandes Vattimo
Support type: Regular Research Grants
FAPESP's process: 11/24028-6 - EFFECT OF PHOSPHODIESTERASE-5 INIBITOR IN ISCHEMIC ACUTE KIDNEY INJURY IN RATS
Grantee:Mirian Watanabe
Support type: Scholarships in Brazil - Post-Doctorate