Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication

Full text
Author(s):
Schlottfeldt, Fabio dos Santos [1] ; Fernandes, Sheila Marques [1] ; Martins, Daniel Malisani [1] ; Cordeiro, Priscilla [1] ; da Fonseca, Cassiane Dezoti [1] ; Watanabe, Mirian [1] ; Fernandes Vattimo, Maria de Fatima [2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Escola Enfermagem, Sao Paulo - Brazil
[2] Univ Sao Paulo, Escola Enfermagem, Dept Enfermagem Med Cirurg, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Revista da Escola de Enfermagem da USP; v. 49, n. SI, p. 73-78, FEB 2015.
Web of Science Citations: 2
Abstract

Objective: To evaluate the effect of diosmin and hesperidin flavonoids in the prevention of amphotericin B nephrotoxicity, through an experimental model on rats. Method: Adult, male Wistar rats were distributed into the following groups: saline; diosmin hesperidin (animals that received 50 mg/kg of diosmin hesperidin, drinking water, for ten days); amphotericin B (animals that received 15 mg/kg/day of amphotericin B through intraperitoneal treatment for five days); amphotericin B+diosmin hesperidin. Renal function, fractional excretion of sodium; potassium and magnesium and oxidative metabolites were evaluated. Results: Treatment with amphotericin B reduced renal function, as shown by the clearance of creatinine, increased tubular function markers and fractional excretion of sodium, potassium, magnesium and oxidative metabolites. Pre-treatment with diosmin hesperidin ameliorated clearance of creatinine and reduced tubular and oxidative injury. Conclusion: Administration of amphotericin B resulted in reduction of renal function with tubular injury, and diosmin hesperidin showing an antioxidant protective effect on the kidneys. (AU)

FAPESP's process: 11/24028-6 - EFFECT OF PHOSPHODIESTERASE-5 INIBITOR IN ISCHEMIC ACUTE KIDNEY INJURY IN RATS
Grantee:Mirian Watanabe
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/26560-2 - Iodinated contrast induced acute kidney injury in diabetic and nephropathy diabetic in rats
Grantee:Maria de Fatima Fernandes Vattimo
Support Opportunities: Regular Research Grants