Experimental maxillary sinus augmentation using a highly bioactive glass ceramic

Autor(es)

Vivan, Rodrigo Ricci ^[1] ; Mecca, Carlos Eduardo ^[2] ; Biguetti, Claudia Cristina ^[3] ; Muniz Renno, Ana Claudia ^[4] ; Okamoto, Roberta ^{[5, 6]} ; Cavenago, Bruno Cavalini ^[1] ; Duarte, Marco Hungaro ^[1] ; Matsumoto, Mariza Akemi ^{[5, 7]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo FOB USP, Bauru Sch Dent, Dept Dent Endodont & Dent Mat, BR-17012901 Bauru, SP - Brazil

^[2] Sagrado Coracao Univ USC, Oral Biol Masters Program, BR-17011160 Bauru, SP - Brazil

^[3] Univ Sao Paulo FOB USP, Bauru Sch Dent, Oral Biol Doctorals Program, BR-17012901 Bauru, SP - Brazil

^[4] Univ Fed Sao Paulo, Dept Biosci, BR-11060001 Santos, SP - Brazil

^[5] Sao Paulo State Univ FOA UNESP, Aracatuba Sch Dent, Dept Basic Sci, BR-16015050 Aracatuba, SP - Brazil

^[6] CNPq Conselho Nacl Dev Cient & Tecnol, Brasilia, DF - Brazil

^[7] Sagrado Coracao Univ, USC, Oral Biol Doctorals Program, Bauru - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE; v. 27, n. 2 FEB 2016.
• Citações Web of Science: 7

Resumo

Physicochemical characteristics of a biomaterial directly influence its biological behavior and fate. However, anatomical and physiological particularities of the recipient site also seem to contribute with this process. The present study aimed to evaluate bone healing of maxillary sinus augmentation using a novel bioactive glass ceramic in comparison with a bovine hydroxyapatite. Bilateral sinus augmentation was performed in adult male rabbits, divided into 4 groups according to the biomaterial used: BO-particulate bovine HA Bio-Oss (R) (BO), BO? G-particulate bovine HA ? particulate autogenous bone graft (G), BS-particulate glass ceramic (180-212 mu m) Biosilicate (R) (BS), and BS+G-particulate glass ceramic + G. After 45 and 90 days, animals were euthanized and the specimens prepared to be analyzed under light and polarized microscopy, immunohistochemistry, scanning electron microscopy (SEM), and micro-computed tomography (mu CT). Results revealed different degradation pattern between both biomaterials, despite the association with bone graft. BS caused a more intense chronic inflammation with foreign body reaction, which led to a difficulty in bone formation. Besides this evidence, SEM and mu CT confirmed direct contact between newly formed bone and biomaterial, along with osteopontin and osteocalcin immunolabeling. Bone matrix mineralization was late in BS group but became similar to BO at day 90. These results clearly indicate that further studies about Biosilicate (R) are necessary to identify the factors that resulted in an unfavorable healing response when used in maxillary sinus augmentation. (AU)

• Processo FAPESP: 09/17294-1 - Estudo da reparação óssea em defeitos realizados em calvária de coelhos utilizando vitrocerâmica bioativa: biosilicato
• Beneficiário: Gustavo Caviquioli
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica