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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Resistance training prevents the cardiovascular changes caused by high-fat diet

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Autor(es):
Speretta, Guilherme F. [1] ; Silva, Andre A. [1] ; Vendramini, Regina C. [2] ; Zanesco, Angelina [3] ; Delbin, Maria A. [4] ; Menani, Jose V. [1] ; Bassi, Mirian [1] ; Colombari, Eduardo [1] ; Colombari, Debora S. A. [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Sch Dent, Dept Physiol & Pathol, Rua Humaita 1680, BR-14801903 Araraquara, SP - Brazil
[2] UNESP, Sch Pharmaceut Sci, Dept Clin Anal, Araraquara, SP - Brazil
[3] UNESP, Inst Biosci, Dept Phys Educ, Rio Claro, SP - Brazil
[4] Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Life Sciences; v. 146, p. 154-162, FEB 1 2016.
Citações Web of Science: 11
Resumo

Aims: Aerobic exercise is indicated for prevention and treatment of obesity-induced cardiovascular disorders. Although the resistance training (RT) may also produce effects similar to aerobic exercise, this is not completely clear yet. In the present study, we tested if RT in moderate intensity might prevent alterations in blood pressure (BP), sympathetic modulation of systolic blood pressure (SBP), baroreflex function and the changes in renin-angiotensin system (RAS) and cytokines mRNA expression within the nucleus of the tract solitary (NTS) in rats fed with high-fat diet (HFD). Main methods: Male Holtzman rats (300-320 g) were divided into 4 groups: sedentary with standard chow diet (SED-SD); sedentary with high-fat diet (SED-HFD); RT with standard chow diet (RT-SD); and RT with high-fat diet (RT-HFD). The trained groups performed a total of 10 weeks of moderate intensity RT in a vertical ladder. In the first 3 weeks all experimental groups were fed with SD. In the next 7 weeks, the SED-HFD and RT-HFD groups were fed with HFD. Key findings: In SED-HFD, BP and sympathetic modulation of SBP increased, whereas baroreflex bradycardic responses were attenuated. RT prevented the cardiovascular and inflammatory responses (increases in tumoral necrosis factor-alpha and interleukin-1 beta) produced by HID in SED rats. The anti-inflammatory interleukin-10, angiotensin type 2 receptor. Mas receptor and angiotensin converting enzyme 2 mRNA expressions in the NTS increased in the RT-HFD compared to SED-HFD. Significance: The data demonstrated that moderate intensity RT prevented obesity-induced cardiovascular disorders simultaneously with reduced inflammatory responses and modifications of RAS in the NTS. (C) 2016 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 13/13118-0 - Participação do sistema melanocortina e sistema renina-angiotensina nas alterações cardiorrespiratórias em ratos submetidos à dieta hiperlipídica
Beneficiário:Guilherme Fleury Fina Speretta
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 11/50770-1 - Mecanismos neurais de regulação do equilíbrio hidroeletrolítico e controle cardiorrespiratório
Beneficiário:José Vanderlei Menani
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/14850-6 - Função colinérgica cardiorrespiratória no núcleo do trato solitário
Beneficiário:André Luis Aguiar Silva
Linha de fomento: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico