| Texto completo | |
| Autor(es): Mostrar menos - |
Fonseca, Felipe P.
[1, 2]
;
Bingle, Lynne
[2]
;
Santos-Silva, Alan R.
[1]
;
Lopes, Marcio A.
[1]
;
de Almeida, Oslei P.
[1]
;
de Andrade, Bruno A. B.
[3]
;
Mariano, Fernanda V.
[1]
;
Kowalski, Luiz P.
[4]
;
Rangel, Ana L. C. A.
[5]
;
Martins, Manoela D.
[6, 7]
;
Meurer, Luise
[6, 7]
;
Speight, Paul M.
[2]
;
Vargas, Pablo A.
[8, 1]
Número total de Autores: 13
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, Piracicaba Dent Sch & Fac Med, Piracicaba - Brazil
[2] Univ Sheffield, Sch Clin Dent, Dept Oral & Maxillofacial Pathol, Sheffield, S Yorkshire - England
[3] Univ Fed Rio de Janeiro, Sch Dent, Rio De Janeiro - Brazil
[4] AC Camargo Canc Ctr, Dept Otorhinolaryngol Head & Neck Surg, Sao Paulo - Brazil
[5] State Univ Western Parana, Sch Dent, Cascavel - Brazil
[6] Univ Fed Rio Grande do Sul, Sch Med, BR-90046900 Porto Alegre, RS - Brazil
[7] Univ Fed Rio Grande do Sul, Sch Dent, BR-90046900 Porto Alegre, RS - Brazil
[8] Univ Pretoria, Fac Hlth Sci, Sch Dent, Dept Oral Pathol & Oral Biol, ZA-0002 Pretoria - South Africa
Número total de Afiliações: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 45, n. 2, p. 119-126, FEB 2016. |
| Citações Web of Science: | 4 |
| Resumo | |
BackgroundSalivary gland tumors (SGT) account for 3-10% of all head and neck neoplasms, and little is known about their angiogenic properties. Despite semaphorins and neuropilins have been demonstrated to be prognostic determinants in many human cancers, they remain to be investigated in SGT. Therefore, the objective of this study was to analyze the clinical significance of the expression of class 3 semaphorins A (Sema3A) and B (Sema3B) and neuropilins-1 (Np-1) and neuropilins-2 (Np-2), in SGT. MethodsTwo hundred and forty-eight SGT were organized in tissue microarray paraffin blocks and expression of CD34, Sema3A, Sema3B, Np-1, and Np-2 was determined through immunohistochemistry. The immunoreactions were quantified using digital algorithms and the results correlated with clinicopathological parameters. ResultsMalignant tumors had an increased vascular density than their benign counterparts and their increased vascular area significantly correlated with recurrences (P<0.05). Patients older than 40years and the presence of recurrences determined an inferior survival rate (P=0.0057 and P=0.0303, respectively). In normal salivary glands, Np-1 and Np-2 expression was restricted to ductal cells, whereas Sema3A and Sema3B were positive in the serous acinar compartment. Tumors were positive for all markers and the co-expression of Np-1/Np-2 significantly correlated with the presence of paresthesia and advanced stages of the tumors (P=0.01 and P=0.04, respectively). ConclusionSema3A, Sema3B, Np-1, and Np-2 may be involved in the pathogenesis of SGT, but their expression did not present a statistically significant prognostic potential in this study. (AU) | |
| Processo FAPESP: | 12/07519-9 - Semaphorinas e neuropilinas em tumores de glândulas salivares |
| Beneficiário: | Felipe Paiva Fonseca |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 09/53839-2 - Criação do Laboratório de Patologia Digital através do uso do escaneador de lâminas histológicas (Aperio® Scanscope CS) |
| Beneficiário: | Oslei Paes de Almeida |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |
| Processo FAPESP: | 12/10781-7 - Análise da expressão de citoqueratinas, do padrão angiogênico, proliferativo e de conteúdo de DNA celular de tumores de glândulas salivares |
| Beneficiário: | Pablo Agustin Vargas |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |