LACK OF REPRODUCTIVE TOXICITY IN ADULT MALE RATS EXPOSED TO INTERFERON-ALPHA

Autor(es)

Rosa, Josiane de Lima ^[1] ; Cavariani, Marilia Martins ^[1] ; Borges, Cibele dos Santos ^[1] ; Araujo Leite, Gabriel Adan ^[1] ; Anselmo-Franci, Janete Aparecida ^[2] ; Kempinas, Wilma De Grava ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, Inst Biosci, Dept Morphol, Lab Biol & Toxicol Reprod & Dev, BR-18618970 Botucatu, SP - Brazil

^[2] Univ Sao Paulo, Sch Dent, Dept Morphol Stomatol & Physiol, BR-14049 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES; v. 78, n. 20, p. 1288-1298, OCT 18 2015.
• Citações Web of Science: 0

Resumo

Interferon-alpha (IFN-), a type I IFN, is a protein with antiviral, antiproliferative, and immunoregulatory activities, widely used in the treatment of several types of cancers as well as hepatitis B and C. Decrease of libido and erectile dysfunction are commonly reported by male patients during treatment of chronic hepatitis C with IFN-. However, IFN therapy-associated underlying factors attributed to sexual dysfunction are still not well defined. Currently, there are few studies investigating the effects of IFN on male reproductive system functions. Given that, the aim of the present investigation was to examine effects of subchronic exposure to IFN- (5 x 10(4) U/kg and 10 x 10(4) U/kg, 30 d) on serum hormones, sperm parameters, fertility, and testicular and epididymal hystopathology and morphometry in adult male Wistar rats. None of the evaluated parameters was markedly altered by IFN-. Thus, our results suggest that exposure to IFN-, in this experimental design, did not adversely affect sperm quality and fertile capacity of male rats. (AU)

• Processo FAPESP: 12/13307-4 - Efeitos do interferon alfa sobre paramêtros reprodutivos de ratos machos, com ênfase sobre aspectos moleculares das barreiras hemato-testicular e hemato-epididimária
• Beneficiário: Josiane de Lima Rosa
• Modalidade de apoio: Bolsas no Brasil - Mestrado