Low- and high-frequency transcutaneous electrical nerve stimulation have no deleterious or teratogenic effects on pregnant mice

Autor(es)

Yokoyama, L. M. ^[1] ; Pires, L. A. ^[2] ; Goncalves Ferreira, E. A. ^[1] ; Casarotto, R. A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Phys Therapy Speech Therapy & Occupat Therap, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PHYSIOTHERAPY; v. 101, n. 2, p. 214-218, JUN 2015.
• Citações Web of Science: 0

Resumo

Objective To evaluate the effects of application of transcutaneous electrical nerve stimulation (TENS) at low and high frequencies to the abdomens of Swiss mice throughout pregnancy. Design Experimental animal study. Setting Research laboratory. Participants Thirty Swiss mice received TENS throughout pregnancy. They were divided into three groups (n = 10): placebo, low-frequency TENS (LF group) and high-frequency TENS (HF group). Interventions In the placebo group, the electrodes were applied to the abdominal region without any electrical current. In the LF group, the frequency was 10 Hz, pulse duration was 200 us and intensity started at 2 mA. In the HF group, the same parameters were applied and the frequency was 150 Hz. All stimulation protocols were applied for 20 min/day from Day 0 until Day 20. Main outcome measures The pregnant mice were weighed on Days 0, 7, 14 and 20 to verify weekly weight gain by two-way analysis of variance. The numbers of fetuses, placentas, implantations, resorptions and major external fetal malformations on Day 20 were analysed using the Kruskal Wallis test. Results No significant differences were found between the placebo and TENS groups (P > 0.05). Conclusion Application of low- and high-frequency TENS to the abdomens of pregnant mice did not cause any deleterious or major teratogenic effects. (C) 2014 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 09/09179-8 - Comparação entre as freqüências baixa e alta da estimulação elétrica nervosa transcutânea na prenhez da rata albina
• Beneficiário: Raquel Aparecida Casarotto
• Modalidade de apoio: Auxílio à Pesquisa - Regular