Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetes

Autor(es)

Quinteiro, Hugo ^[1] ; Buzin, Morgana ^[1] ; Conti, Filipe Fernandes ^[1] ; Dias, Danielle da Silva ^[1] ; Figueroa, Diego ^[2] ; Llesuy, Susana ^[3] ; Irigoyen, Maria-Claudia ^[2] ; Sanches, Iris Callado ^[1] ; de Angelis, Katia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Nove de Julho, Lab Translat Physiol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, Sao Paulo - Brazil

^[3] Univ Buenos Aires, Fac Farm & Bioquim, RA-1113 Buenos Aires, DF - Argentina

• Tipo de documento: Artigo Científico
• Fonte: MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY; v. 22, n. 5, p. 534-541, MAY 2015.
• Citações Web of Science: 12

Resumo

Objective: The aim of this study was to evaluate the effects of aerobic exercise training or resistance exercise training on cardiac morphometric, functional, and oxidative stress parameters in rats with ovarian hormone deprivation and diabetes. Methods: Female Wistar rats (200-220 g) were divided into a sham-operated group (euglycemic sham-operated sedentary {[}ES]; n = 8) and three ovariectomized (bilateral removal of ovaries) and diabetic (streptozotocin 50 mg/kg IV) groups as follows: diabetic ovariectomized sedentary (DOS; n = 8), diabetic ovariectomized undergoing aerobic exercise training (DOTA; n = 8), and diabetic ovariectomized undergoing resistance exercise training (DOTR; n = 8). After 8 weeks of resistance (ladder) or aerobic (treadmill) exercise training, left ventricle function and morphometry were evaluated by echocardiography, whereas oxidative stress was evaluated at the left ventricle. Results: The DOS group presented with increased left ventricle cavity in diastole and relative wall thickness (RWT), and these changes were attenuated in both DOTA and DOTR groups. Systolic and diastolic function was impaired in the DOS group compared with the ES group, and only the DOTA group was able to reverse this dysfunction. Lipoperoxidation and glutathione redox balance were improved in both trained groups compared with the DOS group. Glutathione peroxidase and superoxide dismutase were higher in the DOTA group than in the other studied groups. Correlations were observed between lipoperoxidation and left ventricle cavity in diastole (r = 0.55), between redox balance and RWT (r = 0.62), and between lipoperoxidation and RWT (r = -0.60). Conclusions: Aerobic exercise training and resistance exercise training promote attenuation of cardiac morphometric dysfunction associated with a reduction in oxidative stress in an experimental model of diabetes and menopause. However, only dynamic aerobic exercise training is able to attenuate systolic and diastolic dysfunction under this condition. (AU)

• Processo FAPESP: 12/20141-5 - Efeitos do treinamento físico aeróbio, resistido ou combinado em modelos experimentais de disfunções cardiometabólicas associadas à privação dos hormônios ovarianos
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/52419-4 - Papel do estresse oxidativo e do controle autonomico da circulacao na resistencia do miocardio a injuria isquemica no diabete experimental
• Beneficiário: Georgia Orsi Candido
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/57595-5 - Efeitos do treinamento físico no controle autônomo cardiovascular em fêmeas saudáveis e submetidas à privação dos hormônios ovarianos: papel do estresse oxidativo
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores