Peritrabecular clefting in fibrous dysplasia of the jaws: an important histopathologic feature for differentiating fibrous dysplasia from central ossifying fibroma

Autor(es)

Prado Ribeiro, Ana Carolina ; Carlos, Roman ^[1] ; Speight, Paul M. ^[2] ; Hunter, Keith D. ^[2] ; Santos-Silva, Alan Roger ; de Almeida, Oslei Paes ; Vargas, Pablo Agustin ^[3]

Afiliação do(s) autor(es)

^[1] Hosp Herrera Lierandi, Ctr Clin Cabeza & Cuello, Guatemala City - Guatemala

^[2] Univ Sheffield, Sch Clin Dent, Acad Unit Oral & Maxillofacial Pathol, Sheffield, S Yorkshire - England

^[3] Campinas State Univ UNICAMP, Piracicaba Dent Sch, Dept Oral Diag, Oral Pathol Area, BR-13414903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 114, n. 4, p. 503-508, OCT 2012.
• Citações Web of Science: 9

Resumo

Objective. The aim of this multicenter study was to perform a histomorphometric analysis of peritrabecular clefting in fibrous dysplasia (FD) in an attempt to obtain data that could be useful for distinguishing between FD and ossifying fibroma (OF). Study Design. A clinicopathologic analysis was performed in 68 patients diagnosed with FD and 37 patients diagnosed with OF. Histologic sections were scanned using an Aperio ScanScope CS. A histomorphometric analysis was performed with the aid of an image analyzer (UTHSCSA Image Tool 3.0 version) on 37 randomly selected samples of FD, and the results were compared with the 37 OF specimens. Results. The presence of peritrabecular clefting was observed in 32 (86.5%) cases of FD, whereas no case of OF presented peritrabecular clefting. Conclusions. Peritrabecular clefting may be a hallmark of the lesions in patients with FD, and it may be a valuable microscopic feature for distinguishing it from OF. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:503-508) (AU)

• Processo FAPESP: 09/53839-2 - Criação do Laboratório de Patologia Digital através do uso do escaneador de lâminas histológicas (Aperio® Scanscope CS)
• Beneficiário: Oslei Paes de Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 08/53025-2 - Estudo clinicopatologico, imunoistoquimico, molecular e de ultraestrutura em casos de displasia fibrosa, fibroma ossificante e osteossarcoma dos ossos gnaticos.
• Beneficiário: Ana Carolina Prado Ribeiro e Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado