Co(III)-Catalyzed C-H Activation/Formal S-N-Type Reactions: Selective and Efficient Cyanation, Halogenation, and Allylation

Autor(es)

Yu, Da-Gang ^[1] ; Gensch, Tobias ^[1] ; de Azambuja, Francisco ^[1] ; Vasquez-Cespedes, Suhelen ^[1] ; Glorius, Frank ^[1]

Afiliação do(s) autor(es)

^[1] Univ Munster, Inst Organ Chem, D-48149 Munster - Germany

• Tipo de documento: Artigo Científico
• Fonte: Journal of the American Chemical Society; v. 136, n. 51, p. 17722-17725, DEC 24 2014.
• Citações Web of Science: 320

Resumo

The first cobalt-catalyzed cyanation, halogenation, and allylation via C-H activation have been realized. These formal S-N-type reactions generate valuable (hetero)aryl/alkenyl nitriles, iodides, and bromides as well as allylated indoles using a bench-stable Co(III) catalyst. High regio- and mono-selectivity were achieved for these reactions. Additionally, allylation proceeded efficiently with a turnover number of 2200 at room temperature, which is unprecedented for this Co(III) catalyst. Alkenyl substrates and amides have been successfully utilized in Cp{*}Co(III)-catalyzed C-H activation for the first time. (AU)

• Processo FAPESP: 13/14209-9 - Desenvolvimento de uma nova reação de Fujiwara-Moritani assimétrica intermolecular: uma nova ferramenta sintética para obter unidades diariletano biologicamente ativas
• Beneficiário: Francisco de Azambuja
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado