Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Co(III)-Catalyzed C-H Activation/Formal S-N-Type Reactions: Selective and Efficient Cyanation, Halogenation, and Allylation

Full text
Author(s):
Yu, Da-Gang [1] ; Gensch, Tobias [1] ; de Azambuja, Francisco [1] ; Vasquez-Cespedes, Suhelen [1] ; Glorius, Frank [1]
Total Authors: 5
Affiliation:
[1] Univ Munster, Inst Organ Chem, D-48149 Munster - Germany
Total Affiliations: 1
Document type: Journal article
Source: Journal of the American Chemical Society; v. 136, n. 51, p. 17722-17725, DEC 24 2014.
Web of Science Citations: 320
Abstract

The first cobalt-catalyzed cyanation, halogenation, and allylation via C-H activation have been realized. These formal S-N-type reactions generate valuable (hetero)aryl/alkenyl nitriles, iodides, and bromides as well as allylated indoles using a bench-stable Co(III) catalyst. High regio- and mono-selectivity were achieved for these reactions. Additionally, allylation proceeded efficiently with a turnover number of 2200 at room temperature, which is unprecedented for this Co(III) catalyst. Alkenyl substrates and amides have been successfully utilized in Cp{*}Co(III)-catalyzed C-H activation for the first time. (AU)

FAPESP's process: 13/14209-9 - Development of a new intermolecular asymmetric Fujiwara-Moritani reaction: a new synthetic tool to obtain biologically active moieties
Grantee:Francisco de Azambuja
Support Opportunities: Scholarships abroad - Research Internship - Doctorate