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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Co(III)-Catalyzed C-H Activation/Formal S-N-Type Reactions: Selective and Efficient Cyanation, Halogenation, and Allylation

Full text
Author(s):
Yu, Da-Gang [1] ; Gensch, Tobias [1] ; de Azambuja, Francisco [1] ; Vasquez-Cespedes, Suhelen [1] ; Glorius, Frank [1]
Total Authors: 5
Affiliation:
[1] Univ Munster, Inst Organ Chem, D-48149 Munster - Germany
Total Affiliations: 1
Document type: Journal article
Source: Journal of the American Chemical Society; v. 136, n. 51, p. 17722-17725, DEC 24 2014.
Web of Science Citations: 320
Abstract

The first cobalt-catalyzed cyanation, halogenation, and allylation via C-H activation have been realized. These formal S-N-type reactions generate valuable (hetero)aryl/alkenyl nitriles, iodides, and bromides as well as allylated indoles using a bench-stable Co(III) catalyst. High regio- and mono-selectivity were achieved for these reactions. Additionally, allylation proceeded efficiently with a turnover number of 2200 at room temperature, which is unprecedented for this Co(III) catalyst. Alkenyl substrates and amides have been successfully utilized in Cp{*}Co(III)-catalyzed C-H activation for the first time. (AU)

FAPESP's process: 13/14209-9 - Development of a new intermolecular asymmetric Fujiwara-Moritani reaction: a new synthetic tool to obtain biologically active moieties
Grantee:Francisco de Azambuja
Support Opportunities: Scholarships abroad - Research Internship - Doctorate