Development of a new intermolecular asymmetric Fujiwara-Moritani reaction: a new synthetic tool to obtain biologically active moieties

• Grant number: 13/14209-9
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date until: September 01, 2013
• End date until: August 31, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Carlos Roque Duarte Correia
• Grantee: Francisco de Azambuja
• Supervisor: Frank Glorius
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: University of Munster, Germany
• Associated to the scholarship: 10/11068-7 - C-H activations catalysed by Pd(II) and Rh(III): methodological and mechanistic studies to the synthesis of diarylethane and congeners and evaluations of its biological activity, BP.DR

Abstract

This proposal aims at putting together the last findings in my PhD work related to the Fujiwara's hydroarylation of alkynes and the later achievements of the research group on the asymmetric Heck-Matsuda reaction. Our goal is the development of new synthetic tools using the metal catalyzed C-H activation as the main strategy to provide enantioenriched compounds in a practical and efficient way. The end products envisioned to emerge from this synthetic strategy are planned to feed our medicinal chemistry project, which has the 1,1-diarylethane class of bioactive compounds as a general objective. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

YU, DA-GANG; GENSCH, TOBIAS; DE AZAMBUJA, FRANCISCO; VASQUEZ-CESPEDES, SUHELEN; GLORIUS, FRANK. Co(III)-Catalyzed C-H Activation/Formal S-N-Type Reactions: Selective and Efficient Cyanation, Halogenation, and Allylation. Journal of the American Chemical Society, v. 136, n. 51, p. 17722-17725, DEC 24 2014. (13/14209-9)

YU, DA-GANG; DE AZAMBUJA, FRANCISCO; GENSCH, TOBIAS; DANILIUC, CONSTANTIN G.; GLORIUS, FRANK. The C-H Activation/1,3-Diyne Strategy: Highly Selective Direct Synthesis of Diverse Bisheterocycles by Rh-III Catalysis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 53, n. 36, p. 9650-9654, SEP 1 2014. (13/14209-9)

YU, DA-GANG; DE AZAMBUJA, FRANCISCO; GLORIUS, FRANK. alpha-MsO/TsO/Cl Ketones as Oxidized Alkyne Equivalents: Redox-Neutral Rhodium(III)-Catalyzed C-H Activation for the Synthesis of N-Heterocycles. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 53, n. 10, p. 2754-2758, MAR 3 2014. (13/14209-9)