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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The C-H Activation/1,3-Diyne Strategy: Highly Selective Direct Synthesis of Diverse Bisheterocycles by Rh-III Catalysis

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Author(s):
Yu, Da-Gang [1] ; de Azambuja, Francisco [1] ; Gensch, Tobias [1] ; Daniliuc, Constantin G. [1] ; Glorius, Frank [1]
Total Authors: 5
Affiliation:
[1] Univ Munster, Inst Organ Chem, D-48149 Munster - Germany
Total Affiliations: 1
Document type: Journal article
Source: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION; v. 53, n. 36, p. 9650-9654, SEP 1 2014.
Web of Science Citations: 82
Abstract

The reactivity and selectivity of 1,3-diynes in transition-metal-catalyzed C-H activation is exploited to quickly assemble diverse polysubstituted bisheterocycles, which are highly important but difficult to access. By using the C-H activation/1,3-diyne strategy, we overcame the challenges of selectivity (chemo-, regio-, and mono-/diannulation) and constructed seven kinds of adjacent bisheterocycles through the formation of four strategic bonds with high efficiency and high selectivity. (AU)

FAPESP's process: 13/14209-9 - Development of a new intermolecular asymmetric Fujiwara-Moritani reaction: a new synthetic tool to obtain biologically active moieties
Grantee:Francisco de Azambuja
Support Opportunities: Scholarships abroad - Research Internship - Doctorate