| Texto completo | |
| Autor(es): |
Fernandes de Souza, Rafael Toledo
[1]
;
Lewczuk Gerhardt, Guenther Johannes
[2]
;
Schoenwald, Suzana Veiga
[3, 4]
;
Rybarczyk-Filho, Jose Luiz
[1]
;
Lemke, Ney
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Paulista, UNESP, Dept Fis & Biofis, Botucatu, SP - Brazil
[2] Univ Caxias do Sul, Dept Quim & Fis, Caxias Do Sul - Brazil
[3] Hosp Clin Porto Alegre, Neurol Sect, Porto Alegre, RS - Brazil
[4] Hosp Clin Porto Alegre, Pulmonol Sect, Porto Alegre, RS - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PLoS One; v. 11, n. 3 MAR 10 2016. |
| Citações Web of Science: | 7 |
| Resumo | |
Sleep spindles occur thousands of times during normal sleep and can be easily detected by visual inspection of EEG signals. These characteristics make spindles one of the most studied EEG structures in mammalian sleep. In this work we considered global spindles, which are spindles that are observed simultaneously in all EEG channels. We propose a methodology that investigates both the signal envelope and phase/frequency of each global spindle. By analysing the global spindle phase we showed that 90% of spindles synchronize with an average latency time of 0.1 s. We also measured the frequency modulation ( chirp) of global spindles and found that global spindle chirp and synchronization are not correlated. By investigating the signal envelopes and implementing a homogeneous and isotropic propagation model, we could estimate both the signal origin and velocity in global spindles. Our results indicate that this simple and non-invasive approach could determine with reasonable precision the spindle origin, and allowed us to estimate a signal speed of 0.12 m/s. Finally, we consider whether synchronization might be useful as a non-invasive diagnostic tool. (AU) | |
| Processo FAPESP: | 13/02018-4 - Aprendizado de máquina em biologia molecular de sistemas (AMBiS) aplicação em letalidade sintética, genes condicionalmente essenciais e transcrição gênica cooperativa |
| Beneficiário: | Ney Lemke |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 12/22413-2 - Dinâmica de grafoelementos do sono e seus impactos na neurofisiologia de pacientes com apneia obstrutiva através de sinais de eletroencefalografia |
| Beneficiário: | Rafael Toledo Fernandes de Souza |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |