| Texto completo | |
| Autor(es): Mostrar menos - |
Goncalves, Flavia
[1]
;
de Moraes, Miriam Santos
[2]
;
Ferreira, Lorraine Braga
[3]
;
Oliveira Carreira, Ana Claudia
[4]
;
Kossugue, Patricia Mayumi
[4]
;
Cidreira Boaro, Leticia Cristina
[3]
;
Bentini, Ricardo
[1]
;
da Silva Garcia, Celia Regina
[2]
;
Sogayar, Mari Cleide
[5, 4]
;
Arana-Chavez, Victor Elias
[3]
;
Catalani, Luiz Henrique
[1]
Número total de Autores: 11
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Biociencias, Dept Fisiol, BR-05508090 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Odontol, Dept Biomat & Biol Oral, BR-05508000 Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Fac Med, NUCEL NETCEM Nucleo Terapia Celular & Mol, BR-05360130 Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo, SP - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PLoS One; v. 11, n. 3 MAR 31 2016. |
| Citações Web of Science: | 7 |
| Resumo | |
Regeneration of periodontal tissues requires a concerted effort to obtain consistent and predictable results in vivo. The aim of the present study was to test a new family of bioactive polymeric membranes in combination with stem cell therapy for periodontal regeneration. In particular, the novel polyester poly(isosorbide succinate-co-L-lactide) (PisPLLA) was compared with poly(L-lactide) (PLLA). Both polymers were combined with collagen (COL), hydroxyapatite (HA) and the growth factor bone morphogenetic protein-7 (BMP7), and their osteoinductive capacity was evaluated via in vitro and in vivo experiments. Membranes composed of PLLA/COL/HA or PisPLLA/COL/HA were able to promote periodontal regeneration and new bone formation in fenestration defects in rat jaws. According to quantitative real-time polymerase chain reaction (qRT-PCR) and Alizarin Red assays, better osteoconductive capacity and increased extracellular mineralization were observed for PLLA/COL/HA, whereas better osteoinductive properties were associated with PisPLLA/COL/HA. We concluded that membranes composed of either PisPLLA/COL/HA or PLLA/COL/HA present promising results in vitro as well as in vivo and that these materials could be potentially applied in periodontal regeneration. (AU) | |
| Processo FAPESP: | 10/17698-2 - Uso de matrizes poliméricas eletrofiadas e células tronco de polpa dentária e de adipócitos na engenharia dos tecidos periodontais |
| Beneficiário: | Flavia Gonçalves |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 11/51295-5 - Genômica funcional em Plasmodium |
| Beneficiário: | Célia Regina da Silva Garcia |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 11/21442-6 - Polímeros sintéticos e naturais aplicados à engenharia de tecido |
| Beneficiário: | Luiz Henrique Catalani |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |