Fc Gamma Receptor IIA (CD32A) R131 Polymorphism as a Marker of Genetic Susceptibility to Sepsis

Autor(es)

Beppler, Jaqueline ^[1] ; Koehler-Santos, Patricia ^[2] ; Pasqualim, Gabriela ^[3] ; Matte, Ursula ^[4] ; Alho, Clarice Sampaio ^{[5, 6]} ; Dias, Fernando Suparregui ^{[5, 6]} ; Kowalski, Thayne Woycinck ^[3] ; Velasco, Irineu Tadeu ^[1] ; Monteiro, Renato C. ^{[7, 8]} ; da Silva, Fabiano Pinheiro ^{[1, 9]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Emergency Med, BR-01246000 Sao Paulo - Brazil

^[2] Hosp Clin Porto Alegre, Prot & Mol Anal Unit, Expt Res Ctr, Porto Alegre, RS - Brazil

^[3] Univ Fed Rio Grande do Sul, Postgrad Program Genet & Mol Biol, Porto Alegre, RS - Brazil

^[4] Hosp Clin Porto Alegre, Gene Therapy Unit, Expt Res Ctr, Porto Alegre, RS - Brazil

^[5] Pontificia Univ Catolica Rio Grande do Sul, Sch Biosci, Porto Alegre, RS - Brazil

^[6] Pontificia Univ Catolica Rio Grande do Sul, Hosp Sao Lucas, Porto Alegre, RS - Brazil

^[7] Univ Paris Diderot, Ctr Res Inflammat, INSERM, U1149, Paris - France

^[8] Univ Paris Diderot, Ctr Res Inflammat, ERL Cnrs 8252, Paris - France

^[9] Univ Sao Paulo, Fac Med, Lab Emergencias Clin LIM 51, Av Dr Arnaldo, 455 Sala 3189, BR-01246000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Inflammation; v. 39, n. 2, p. 518-525, APR 2016.
• Citações Web of Science: 10

Resumo

Sepsis is a devastating disease that can affect humans at any time between neonates and the elderly and is associated with mortality rates that range from 30 to 80 %. Despite intensive efforts, its treatment has remained the same over the last few decades. Fc receptors regulate multiple immune responses and have been investigated in diverse complex diseases. Fc gamma RIIA (CD32A) is an immunoreceptor, tyrosine-based activation motif-bearing receptor that binds immunoglobulin G and C-reactive protein, important opsonins in host defense. We conducted a study of 702 patients (184 healthy individuals, 171 non-infected critically ill patients, and 347 sepsis patients) to investigate if genetic polymorphisms in the CD32A coding region affect the risk of septic shock. All individuals were genotyped for a variant at position 131 of the Fc gamma RIIA gene. We found that allele G, associated with the R131 genotype, was significantly more frequent in septic patients than in the other groups (p = 0.05). Our data indicate that Fc gamma RIIA genotyping can be used as a marker of genetic susceptibility to sepsis. (AU)

• Processo FAPESP: 12/51468-0 - Role of Fc receptors in bacterial immune evasion
• Beneficiário: Irineu Tadeu Velasco
• Linha de fomento: Auxílio à Pesquisa - Temático