Novel Double-Layered Conduit Containing Highly Bioactive Glass Fibers for Potential Nerve Guide Application

Autor(es)

Souza, Marina Trevelin ^{[1, 2]} ; Peitl, Oscar ^{[1, 2]} ; Zanotto, Edgar Dutra ^{[1, 2]} ; Boccaccini, Aldo R. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, CeRTEV Ctr Res Technol & Educ Vitreous Mat, Rod Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Mat Engn, Vitreous Mat Lab, Rod Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Erlangen Nurnberg, Inst Biomat, D-91058 Erlangen - Germany

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE; v. 7, n. 2, p. 183-194, JUN 2016.
• Citações Web of Science: 6

Resumo

Peripheral nerve injuries are frequent conditions that currently have very few treatment alternatives. This study aimed to incorporate aligned bioactive glass microfibers (that belong to the SiO2-Na2O-K2O-MgO-CaO-P2O5 system) in nanofibrous poly epsilon-caprolactone (PCL) membranes to develop a new biocomposite that is potentially able to facilitate nerve growth and increase the polymer matrix's biological and mechanical properties. For the manufacture of this novel tubular nerve guide, electrospinning of PCL was performed on the surface of bioactive glass fibers, resulting in a two-layer microcomposite. The mechanical strength, bioactivity, wettability, degradation, and permeability of this new material were characterized. The preliminary results indicate that the incorporation of the bioactive glass fibers into PCL led to the development of a highly bioactive biocomposite with significantly improved mechanical properties and wettability compared with the PCL matrix alone. (AU)

• Processo FAPESP: 13/07793-6 - CEPIV - Centro de Ensino, Pesquisa e Inovação em Vidros
• Beneficiário: Edgar Dutra Zanotto
• Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 14/01726-8 - Desenvolvimento de biocompósitos com reforço de fibras de vidro bioativas para aplicação na engenharia de tecidos
• Beneficiário: Marina Trevelin Souza
• Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado