Simultaneous Quantification of the 8 Human Herpesviruses in Allogeneic Hematopoietic Stem Cell Transplantation

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Alvarenga Gomes de Oliveira, Paulo Guilherme ^[1] ; Hiramoto Ueda, Miriam Yurika ^[2] ; Real, Juliana Monte ^[3] ; Moreira, Eloisa de Sa ^[4] ; Rodrigues de Oliveira, Jose Salvador ^[1] ; Goncalves, Matheus Vescovi ^[1] ; Ginani, Valeria Cortez ^[5] ; Wanderley de Oliveira Felix, Olga Margareth ^[5] ; Seber, Adriana ^[5] ; Novis, Yana ^[3] ; Rocha, Vanderson ^{[6, 3]} ; Hernandes Granato, Celso Francisco ^[2] ; Arrais-Rodrigues, Celso ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Disciplina Hematol & Hemoterapia, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Disciplina Doencas Infecciosas & Parasitarias, Sao Paulo - Brazil

^[3] Hosp Sirio Libanes, Inst Ensino & Pesquisa, Ctr Oncol, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Biociencias, Dept Genet & Biol Evolut, Sao Paulo - Brazil

^[5] Inst Oncol Pediat, Sao Paulo - Brazil

^[6] Oxford Univ Hosp, Churchill Hosp, Oxford - England

• Tipo de documento: Artigo Científico
• Fonte: TRANSPLANTATION; v. 100, n. 6, p. 1363-1370, JUN 2016.
• Citações Web of Science: 1

Resumo

Background. Human herpesviruses may cause severe complications after allogeneic hematopoietic stem cell transplantation (HSCT). However, the impact of some of these infections on transplant outcomes is still unclear. A prospective survey on the incidence and clinical features of herpesviruses infections after HSCT has not yet been conducted in Brazilian patients, and the impact of these infections on HSCT outcome remains unclear. Methods. We prospectively analyzed the incidence of infection of the eight human herpesviruses simultaneously in 1 045 peripheral blood samples from 98 allogeneic HSCT recipients. Samples were collected weekly starting at the time of transplant until day + 100. All herpesviruses were screened and quantified in plasma by quantitative real-time polymerase chain reaction. Median follow up time was 24 months. Results. The incidences of infection for each herpesvirus were as follows: cytomegalovirus (CMV), 44%; human herpesvirus {[}HHV] 6, 18%; HHV8, 6%; Epstein-Barr virus, 3%; herpes simplex virus 1, 3%; varicella zoster virus, 3%; HHV7, 2%; and herpes simplex virus 2, 1%. The CMV infection was significantly more frequent among adults and was associated with a higher risk of developing acute graft-versus-host disease. The HHV6 infection was significantly more frequent after umbilical cord blood transplant and was associated with an increased risk of platelet engraftment failure. There was no significant impact of these infections on the other transplant outcomes. Conclusions. Herpesviruses infections were uncommon after HSCT, except for CMV and HHV6, which, although relatively frequent, had no clinically relevant impact on the outcomes. (AU)

• Processo FAPESP: 08/57498-2 - Quantificação simultânea de herpesvírus e seu impacto clínico em pacientes submetidos a transplante de células progenitoras hematopoéticas
• Beneficiário: Celso Arrais Rodrigues da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular