Mouthwash use and cancer of the head and neck: a pooled analysis from the International Head and Neck Cancer Epidemiology Consortium

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Boffetta, Paolo ^{[1, 2]} ; Hayes, Richard B. ^[3] ; Sartori, Samantha ^{[1, 2]} ; Lee, Yuan-Chin A. ^[4] ; Muscat, Joshua ^[5] ; Olshan, Andrew ^[6] ; Winn, Deborah M. ^[7] ; Castellsague, Xavier ^{[8, 9]} ; Zhang, Zuo-Feng ^[10] ; Morgenstern, Hal ^{[11, 12]} ; Chen, Chu ^[13] ; Schwartz, Stephen M. ^[13] ; Vaughan, Thomas L. ^[13] ; Wunsch-Filho, Victor ^[14] ; Purdue, Mark ^[7] ; Koifman, Sergio ^[15] ; Curado, Maria P. ^[16] ; Vilensky, Marta ^[17] ; Gillison, Maura ^[18] ; Fernandez, Leticia ^[19] ; Menezes, Ana ^[20] ; Daudt, Alexander W. ^[21] ; Schantz, Stimson ^[22] ; Yu, Guopei ^[23] ; D'Souza, Gypsyamber ^[24] ; Haddad, Robert I. ^[25] ; La Vecchia, Carlo ^[26] ; Hashibe, Mia ^[4]

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^[1] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 - USA

^[2] Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 - USA

^[3] NYU, Sch Med, Div Epidemiol, Dept Populat Hlth, New York, NY - USA

^[4] Univ Utah, Sch Med, Huntsman Canc Inst, Dept Family & Prevent Med, Div Publ Hlth, Salt Lake City, UT - USA

^[5] Penn State Coll Med, Hershey, PA - USA

^[6] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC - USA

^[7] NCI, Bethesda, MD 20892 - USA

^[8] Hosp Llobregat, Catalan Inst Oncol ICO IDIBELL, Barcelona - Spain

^[9] Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Barcelona - Spain

^[10] Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 - USA

^[11] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 - USA

^[12] Univ Michigan, Sch Publ Hlth, Dept Epidemiol & Environm Hlth Sci, Ann Arbor, MI 48109 - USA

^[13] Fred Hutchinson Canc Res Ctr, Seattle, WA - USA

^[14] Univ Sao Paulo, Sao Paulo - Brazil

^[15] Fundacao Oswaldo Cruz, Natl Sch Publ Hlth, Rio De Janeiro - Brazil

^[16] Int Prevent Res Inst, Lyon - France

^[17] Univ Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF - Argentina

^[18] Johns Hopkins Med Inst, Baltimore, MD - USA

^[19] Inst Oncol & Radiobiol, Havana - Cuba

^[20] Univ Fed Pelotas, Pelotas - Brazil

^[21] Hosp Clin Porto Alegre, Porto Alegre, RS - Brazil

^[22] New York Eye & Ear Infirm, New York, NY - USA

^[23] Peking Univ, Med Informat Ctr, Beijing 100871 - Peoples R China

^[24] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD - USA

^[25] Harvard Univ, Sch Med, Dana Farber Canc Inst, 44 Binney St, Boston, MA 02115 - USA

^[26] Univ Milan, Dept Clin Sci & Community Hlth, Milan - Italy

• Tipo de documento: Artigo Científico
• Fonte: European Journal of Cancer Prevention; v. 25, n. 4, p. 344-348, JUL 2016.
• Citações Web of Science: 7

Resumo

Most mouthwashes contain alcohol, a known cause of head and neck cancer (oral cavity, pharynx, larynx), likely through the carcinogenic activity of acetaldehyde, formed in the oral cavity from alcohol. We carried out a pooled analysis of 8981 cases of head and neck cancer and 10090 controls from 12 case-control studies with comparable information on mouthwash use in the International Head and Neck Cancer Epidemiology Consortium. Logistic regression was used to assess the association of mouthwash use with cancers of the oral cavity, oropharynx, hypopharynx, and larynx, adjusting for study, age, sex, pack-years of tobacco smoking, number of alcoholic drinks/day, and education. Compared with never users of mouthwash, the odds ratio (OR) of all head and neck cancers was 1.01 {[}95% confidence interval (CI): 0.94-1.08] for ever users, based on 12 studies. The corresponding ORs of cancer of the oral cavity and oropharynx were 1.11 (95% CI: 1.00-1.23) and 1.28 (95% CI: 1.06-1.56), respectively. OR for all head and neck cancer was 1.15 (95% CI: 1.01-1.30) for use for more than 35 years, based on seven studies (P for linear trend=0.01), and OR 1.31 (95% CI: 1.09-1.58) for use more than one per day, based on five studies (P for linear trend <0.001). Although limited by the retrospective nature of the study and the limited ability to assess risks of mouthwash use in nonusers of tobacco and alcohol, this large investigation shows potential risks for head and neck cancer subsites and in long-term and frequent users of mouthwash. This pooled analysis provides the most precise estimate of the association between mouthwash use and head and neck cancer. (AU)

• Processo FAPESP: 01/01768-2 - Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe
• Beneficiário: José Eluf Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular