Can physical exercise have a protective effect in an animal model of sleep-related movement disorder?

Autor(es)

Esteves, Andrea M. ^[1] ; Lopes, Cleide ^[2] ; Frank, Miriam K. ^[1] ; Arida, Ricardo M. ^[3] ; Frussa-Filho, Roberto ^[4] ; Tufik, Sergio ^[2] ; de Mello, Marco Tulin ^[5]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Fac Ciencias Aplicadas, Rua Pedro Zaccaria 1300, Limeira, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Fisiol, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Dept Farmacol, Sao Paulo - Brazil

^[5] Univ Fed Minas Gerais, Dept Esportes, Belo Horizonte, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brain Research; v. 1639, p. 47-57, MAY 15 2016.
• Citações Web of Science: 0

Resumo

The purpose of the present study was to determine whether physical exercise (PE) has a protective effect in an experimental animal model of sleep-related movement disorder (All dopaminergic nuclei lesions with 6-OHDA). Rats were divided into four groups (Control PE-CTRL/PE, SHAM/PE, All lesion/NPE, All lesion/PE). Two experiments were performed: (1) the rats underwent PE before (2 weeks) and after (4 weeks) the All lesion; and (2) the rats underwent PE only after (4 weeks) the All lesion. Electrode insertion surgery was performed and sleep analyses were conducted over a period of 24 h (baseline and after PE) and analyzed in 6 blocks of 4 h. The results demonstrated that the All lesion produced an increased percentage of wakefulness in the final block of the dark period (37 am) and a significant enhancement of the number of limb movements (LM) throughout the day. Four weeks of PE was important for reducing the number of LMs in the All lesion group in the rats that performed PE before and after the All lesion. However, in the analysis of the protective effect of PE on LM, the results showed that the number of LMs was lower at baseline in the group that had performed 2 weeks of PE prior to the All lesion than in the group that had not previously performed PE. In conclusion, these findings consistently demonstrate that non-pharmacological manipulations had a beneficial effect on the symptoms of sleep-related movement disorder. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 08/50646-6 - Efeitos do exercício físico em um modelo animal de síndrome das pernas inquietas e de movimentos periódicos das pernas
• Beneficiário: Andrea Maculano Esteves
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado