Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres

Autor(es)

Caroline de Oliveira Renó ; Mariana Motisuke

• Tipo de documento: Artigo Científico
• Fonte: MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS; v. 19, n. 6, p. 1388-1392, Dez. 2016.

Resumo

Spherical calcium phosphate cement carriers were synthesized by water/oil emulsion. A 23 factorial design was employed in order to optimize the size and form of the microspheres. Stirring speed, liquid-to-powder ratio and cement paste-to-oil ratio were varied in two different levels and the response variable was the microsphere's sphericity. The results showed that cement's setting reaction was responsible for stabilizing the microspheres within the oil phase resulting in a low crystalline hydroxyapatite. The sizes varied from 6.29 to 64.23 µm. From the factors studied, the stirring velocity and the interaction between the L/P ratio with the P/O ratio are the ones that are more effective in controlling microspheres' sphericity. The results suggest that the methodology studied may provide microspheres with appropriate properties to deliver cells and/or drugs without inducing inflammatory reactions. (AU)

• Processo FAPESP: 13/19642-2 - Cimentos ósseos injetáveis: otimização e controle das propriedades mecânicas, porosidade e taxa de degradação
• Beneficiário: Mariana Motisuke
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/09240-9 - Otimização de cimentos de fosfato de cálcio para aplicação na ortopedia e na engenharia tecidual
• Beneficiário: Mariana Motisuke
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/26248-9 - Cimento de fosfato de cálcio co-dopado com silício e estrôncio: estudo da injetabilidade e otimização das propriedades mecânicas
• Beneficiário: Caroline de Oliveira Renó
• Linha de fomento: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 12/21198-0 - Fabricação de microesferas bioativas e reabsorvíveis de fosfato de cálcio para a liberação controlada de drogas
• Beneficiário: Caroline de Oliveira Renó
• Linha de fomento: Bolsas no Brasil - Mestrado