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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats

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Autor(es):
Matos, Juliana Fernandes ; Americo, Madileine Francely ; Sinzato, Yuri Karen ; Volpato, Gustavo Tadeu ; Cora, Luciana Aparecida ; Freitas Calabresi, Marcos Felipe ; Oliveira, Ricardo Brandt ; Damasceno, Debora Cristina ; Arruda Miranda, Jose Ricardo
Número total de Autores: 9
Tipo de documento: Artigo Científico
Fonte: WORLD JOURNAL OF GASTROENTEROLOGY; v. 22, n. 25, p. 5761-5768, JUL 7 2016.
Citações Web of Science: 7
Resumo

AIM: To correlate gastric contractility, gastrointestinal transit, and hormone levels in non-pregnant (estrous cycle) and pregnant rats using noninvasive techniques. METHODS: Female rats (n = 23) were randomly divided into (1) non-pregnant, (contractility, n = 6; transit, n = 6); and (2) pregnant (contractility, n = 5; transit, n = 6). In each estrous cycle phase or at 0, 7, 14, and 20 d after the confirmation of pregnancy, gastrointestinal transit was recorded by AC biosusceptometry (ACB), and gastric contractility was recorded by ACB and electromyography. After each recording, blood samples were obtained for progesterone and estradiol determination. RESULTS: In the estrous cycle, despite fluctuations of sex hormone levels, no significant changes in gastrointestinal motility were observed. Days 7 and 14 of pregnancy were characterized by significant changes in the frequency of contractions (3.90 +/- 0.42 cpm and 3.60 +/- 0.36 cpm vs 4.33 +/- 0.25 cpm) and gastric emptying (168 +/- 17 min and 165 +/- 15 min vs 113 +/- 15 min) compared with day 0. On these same days, progesterone levels significantly increased compared with control (54.23 +/- 15.14 ng/mL and 129.96 +/- 30.52 ng/mL vs 13.25 +/- 6.31 ng/mL). On day 14, we observed the highest level of progesterone and the lowest level of estradiol compared with day 0 (44.3 +/- 15.18 pg/mL vs 24.96 +/- 5.96 pg/mL). CONCLUSION: Gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying. (AU)

Processo FAPESP: 10/14845-4 - Estudo da motilidade gástrica em ratas prenhes diabéticas e não-diabéticas
Beneficiário:Juliana Fernandes de Matos
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 15/14923-9 - Instrumentação e aplicações por biosusceptometria de corrente alternada: estudos de distribuição de nanopartículas, motilidade e controle da qualidade de formas farmacêuticas sólidas
Beneficiário:José Ricardo de Arruda Miranda
Linha de fomento: Auxílio à Pesquisa - Regular