Memory impairment due to fipronil pesticide exposure occurs at the GABA(A) receptor level, in rats

Autor(es)

Godinho, Antonio Francisco ; Oliveira Souza, Ana Carolina De ; Carvalho, Caio Cristovao ; Horta, Daniel Franca ; De Fraia, Daniel ; Anselmo, Fabio ; Chaguri, Joao Leandro ; Faria, Caique Aparecido

• Tipo de documento: Artigo Científico
• Fonte: Physiology & Behavior; v. 165, p. 28-34, OCT 15 2016.
• Citações Web of Science: 3

Resumo

Fipronil;(F) a pesticide considered of second generation cause various toxic effects in target and non-target organisms including humans in which provoke neurotoxicity, having the antagonism of gamma-amino butyric acid (GABA) as their main mechanism for toxic action. GABAergic system has been involved in processes related to the memory formation and consolidation. The present work studied the importance of GABA to the mechanisms involved in the very early development of fipronil-induced memory impairment in rats. Memory behavior was assessed using new object recognition task (ORT) and eight radial arm maze task (8-RAM) to study effects on cognitive and spatial memory. Locomotor behavior was assessed using open field task (OF). The dose of fipronil utilized was studied through a pilot experiment. The GABA antagonist picrotoxin (P) was used to enhance fipronil effects on GABAergic system. Fipronil or picrotoxin decrease memory studied in ORT and 8-RAM tasks. Additionally, F and P co-exposure enhanced effects on memory compared to controls, F, and P, suggesting strongly a GABAergic effect Weight gain modulation and fipronil in blood were utilized as animal's intoxication indicators. In conclusion, here we report that second-generation pesticides, such as fipronil, can have toxic interactions with the CNS of mammals and lead to memory impairment by modulating the GABAergic system. (C) 2016 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 14/18433-3 - Comportamento de memória em ratos Wistar expostos ao praguicida fipronil
• Beneficiário: Caio Cristovão Carvalho
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 14/18429-6 - Estudo dos efeitos da exposição ao pesticida Fipronil e a picrotoxina, sobre o comportamento de memória em ratos
• Beneficiário: Ana Carolina de Oliveira Souza
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica