Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Memory impairment due to fipronil pesticide exposure occurs at the GABA(A) receptor level, in rats

Full text
Author(s):
Godinho, Antonio Francisco ; Oliveira Souza, Ana Carolina De ; Carvalho, Caio Cristovao ; Horta, Daniel Franca ; De Fraia, Daniel ; Anselmo, Fabio ; Chaguri, Joao Leandro ; Faria, Caique Aparecido
Total Authors: 8
Document type: Journal article
Source: Physiology & Behavior; v. 165, p. 28-34, OCT 15 2016.
Web of Science Citations: 3
Abstract

Fipronil;(F) a pesticide considered of second generation cause various toxic effects in target and non-target organisms including humans in which provoke neurotoxicity, having the antagonism of gamma-amino butyric acid (GABA) as their main mechanism for toxic action. GABAergic system has been involved in processes related to the memory formation and consolidation. The present work studied the importance of GABA to the mechanisms involved in the very early development of fipronil-induced memory impairment in rats. Memory behavior was assessed using new object recognition task (ORT) and eight radial arm maze task (8-RAM) to study effects on cognitive and spatial memory. Locomotor behavior was assessed using open field task (OF). The dose of fipronil utilized was studied through a pilot experiment. The GABA antagonist picrotoxin (P) was used to enhance fipronil effects on GABAergic system. Fipronil or picrotoxin decrease memory studied in ORT and 8-RAM tasks. Additionally, F and P co-exposure enhanced effects on memory compared to controls, F, and P, suggesting strongly a GABAergic effect Weight gain modulation and fipronil in blood were utilized as animal's intoxication indicators. In conclusion, here we report that second-generation pesticides, such as fipronil, can have toxic interactions with the CNS of mammals and lead to memory impairment by modulating the GABAergic system. (C) 2016 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 14/18433-3 - Memory behavior in Wistar rats exposed to the pesticide fipronil
Grantee:Caio Cristovão Carvalho
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 14/18429-6 - Study of the effect of the exposition to the Fipronil pesticide and the picrotoxina, on the behavior of memory in rats
Grantee:Ana Carolina de Oliveira Souza
Support Opportunities: Scholarships in Brazil - Scientific Initiation