Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Reduction of Cerebral and Corpus Callosum Volumes in Childhood-Onset Systemic Lupus Erythematosus: A Volumetric Magnetic Resonance Imaging Analysis

Texto completo
Autor(es):
Lapa, Aline Tamires ; Postal, Mariana ; Sinicato, Nailu Angelica ; Ferreira, Weslley Geraldo ; Bellini, Bruna Siqueira ; Fernandes, Paula Teixeira ; Rittner, Leticia ; Marini, Roberto ; Cendes, Fernando ; Appenzeller, Simone
Número total de Autores: 10
Tipo de documento: Artigo Científico
Fonte: ARTHRITIS & RHEUMATOLOGY; v. 68, n. 9, p. 2193-2199, SEP 2016.
Citações Web of Science: 7
Resumo

Objective. There have been few studies in which the prevalence of cerebral atrophy in childhood-onset systemic lupus erythematosus (SLE) was evaluated using magnetic resonance imaging (MRI) volumetric measurements. This study was undertaken to determine the prevalence of cerebral and corpus callosum atrophy in childhood-onset SLE and to determine the possible relationships between atrophy and clinical, laboratory, and treatment features of the disease. Methods. We included 76 patients with childhood-onset SLE (69 female and 7 male; median age 16 years) and 66 age- and sex-matched healthy controls. Neurologic manifestations were analyzed according to the American College of Rheumatology (ACR) criteria. These SLE patients were further assessed for clinical and laboratory manifestations of SLE, disease activity (using the SLE Disease Activity Index), damage (using the Systemic Lupus International Collaborating Clinics/ACR Damage Index), and current and cumulative drug exposures. Scans were performed with a Philips 3.0T MRI scanner using a standardized protocol. Results. Childhood-onset SLE patients had significantly smaller cerebral and corpus callosum volumes than controls (median cerebral volume 1,067.9 cm(3) versus 1,172.7 cm(3) and median corpus callosum volume 11.6 cm(3) versus 13.7 cm(3); P<0.001). The presence of structural abnormalities was observed in 42 patients (55.3%) with childhood-onset SLE. The presence of cerebral atrophy was associated with anticardiolipin antibodies (aCL) (P=0.02), anti-double-stranded DNA (P=0.02), and cumulative corticosteroid dose (P=0.04). The presence of corpus callosum atrophy was associated with low complement level (P=0.006) and acute confusional state (P=0.01). Serum levels of S100B or high molecular weight neurofilament and the presence of anti-ribosomal P were not associated with atrophy. Conclusion. Structural brain abnormalities were observed in 55.3% of the patients and were associated with neuropsychiatric manifestations, aCL, and corticosteroid use. To determine permanent neurologic damage, longitudinal studies must be conducted in these patients. (AU)

Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
Beneficiário:Fernando Cendes
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 13/09480-5 - Análise longitudinal das alterações nas estruturas de substância branca e cinzenta através da ressonância magnética no lúpus eritematoso sistêmico juvenil
Beneficiário:Aline Tamires Lapa
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 08/02917-0 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no lúpus eritematoso sistêmico
Beneficiário:Simone Appenzeller
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 11/03788-2 - Avaliação longitudinal das interleucinas 4, 6, 10 e 12, do interferon gama e fator de necrose tumoral alfa e associações clínicas e laboratoriais em pacientes com lúpus eritematoso sistêmico
Beneficiário:Mariana Postal Zink de Souza
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 13/01936-0 - Comparação das alterações encontradas no exame de ressonância magnética entre pacientes com lúpus eritematoso sistêmico juvenil e adulto
Beneficiário:Weslley Geraldo Ferreira
Linha de fomento: Bolsas no Brasil - Iniciação Científica