Optical coherence tomography for blood glucose monitoring in vitro through spatial and temporal approaches

Autor(es)

De Pretto, Lucas Ramos ; Yoshimura, Tania Mateus ; Ribeiro, Martha Simoes ; de Freitas, Anderson Zanardi

• Tipo de documento: Artigo Científico
• Fonte: Journal of Biomedical Optics; v. 21, n. 8 AUG 2016.
• Citações Web of Science: 6

Resumo

As diabetes causes millions of deaths worldwide every year, new methods for blood glucose monitoring are in demand. Noninvasive approaches may increase patient adherence to treatment while reducing costs, and optical coherence tomography (OCT) may be a feasible alternative to current invasive diagnostics. This study presents two methods for blood sugar monitoring with OCT in vitro. The first, based on spatial statistics, exploits changes in the light total attenuation coefficient caused by different concentrations of glucose in the sample using a 930-nm commercial OCT system. The second, based on temporal analysis, calculates differences in the decorrelation time of the speckle pattern in the OCT signal due to blood viscosity variations with the addition of glucose with data acquired by a custom built Swept Source 1325-nm OCT system. Samples consisted of heparinized mouse blood, phosphate buffer saline, and glucose. Additionally, further samples were prepared by diluting mouse blood with isotonic saline solution to verify the effect of higher multiple scattering components on the ability of the methods to differentiate glucose levels. Our results suggest a direct relationship between glucose concentration and both decorrelation rate and attenuation coefficient, with our systems being able to detect changes of 65 mg/dL in glucose concentration. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) (AU)

• Processo FAPESP: 13/09311-9 - Utilização de padrões de speckle nas imagens de tomografia por coerência óptica para caracterização de circuitos microfluídicos e microcirculação em tecido
• Beneficiário: Anderson Zanardi de Freitas
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/05492-9 - Caracterização de circuitos microfluídicos utilizando padrões de speckle presentes nas imagens de tomografia por coerência óptica
• Beneficiário: Lucas Ramos de Pretto
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 14/02564-1 - Tratando a meta-inflamação da síndrome metabólica usando terapia com luz de baixa potência
• Beneficiário: Martha Simões Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular