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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Optical coherence tomography for blood glucose monitoring in vitro through spatial and temporal approaches

Full text
Author(s):
De Pretto, Lucas Ramos ; Yoshimura, Tania Mateus ; Ribeiro, Martha Simoes ; de Freitas, Anderson Zanardi
Total Authors: 4
Document type: Journal article
Source: Journal of Biomedical Optics; v. 21, n. 8 AUG 2016.
Web of Science Citations: 6
Abstract

As diabetes causes millions of deaths worldwide every year, new methods for blood glucose monitoring are in demand. Noninvasive approaches may increase patient adherence to treatment while reducing costs, and optical coherence tomography (OCT) may be a feasible alternative to current invasive diagnostics. This study presents two methods for blood sugar monitoring with OCT in vitro. The first, based on spatial statistics, exploits changes in the light total attenuation coefficient caused by different concentrations of glucose in the sample using a 930-nm commercial OCT system. The second, based on temporal analysis, calculates differences in the decorrelation time of the speckle pattern in the OCT signal due to blood viscosity variations with the addition of glucose with data acquired by a custom built Swept Source 1325-nm OCT system. Samples consisted of heparinized mouse blood, phosphate buffer saline, and glucose. Additionally, further samples were prepared by diluting mouse blood with isotonic saline solution to verify the effect of higher multiple scattering components on the ability of the methods to differentiate glucose levels. Our results suggest a direct relationship between glucose concentration and both decorrelation rate and attenuation coefficient, with our systems being able to detect changes of 65 mg/dL in glucose concentration. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) (AU)

FAPESP's process: 13/09311-9 - Use of speckle patterns in optical coherence tomography images for characterization of microfluidic circuits and microcirculation in tissue
Grantee:Anderson Zanardi de Freitas
Support Opportunities: Regular Research Grants
FAPESP's process: 13/05492-9 - Characterization of microfluidic circuits using speckle patterns in optical coherence tomography images
Grantee:Lucas Ramos de Pretto
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 14/02564-1 - Treating metabolic syndrome's metaflammation with low level light therapy
Grantee:Martha Simões Ribeiro
Support Opportunities: Regular Research Grants